Mm00452119_m1

• Gene Symbol: Sirt2
• Gene Name: sirtuin 2
• Gene Aliases: 5730427M03Rik, SIR2L2, Sir2l
• Chromosome Location: Chr.7: 28766752 - 28788665 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Sirt2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001122765.1	NP_001116237.1	8 - 9	680		68
	NM_001122766.1	NP_001116238.1	6 - 7	517		68
	NM_022432.4	NP_071877.3	9 - 10	727		68
GenBank mRNA	AB221570.1	-	9 - 10	632		68
	AF299337.1	-	9 - 10	712		68
	AK014042.1	-	8 - 9	651		68
	AK144431.1	-	8 - 9	624		68
	AK146412.1	-	8 - 9	660		68
	AK183534.1	-	1 - 2	101		68
	BC021439.1	-	9 - 10	731	5039278	68
	KF032392.1	-	9 - 10	669		68

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0700000511.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Sirt2

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
protein deacetylation
autophagy
cell cycle
mitotic nuclear division
nervous system development
negative regulation of cell proliferation
negative regulation of autophagy
negative regulation of peptidyl-threonine phosphorylation
phosphatidylinositol 3-kinase signaling
histone deacetylation
myelination in peripheral nervous system
cell differentiation
regulation of myelination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to oxidative stress
peptidyl-lysine deacetylation
cellular response to hepatocyte growth factor stimulus
negative regulation of protein catabolic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA binding
protein kinase B signaling
cellular lipid catabolic process
regulation of fat cell differentiation
negative regulation of fat cell differentiation
positive regulation of meiotic nuclear division
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
negative regulation of oligodendrocyte differentiation
cell division
meiotic cell cycle
regulation of cell cycle
positive regulation of cell division
positive regulation of attachment of spindle microtubules to kinetochore
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
cellular response to caloric restriction
negative regulation of oligodendrocyte progenitor proliferation
histone H3 deacetylation
histone H4 deacetylation
cellular response to molecule of bacterial origin
cellular response to hypoxia
cellular response to epinephrine stimulus
tubulin deacetylation
positive regulation of execution phase of apoptosis
positive regulation of oocyte maturation
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of defense response to bacterium
ripoptosome assembly involved in necroptotic process
negative regulation of reactive oxygen species metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Function(s)

chromatin binding
histone deacetylase activity
protein binding
transcription factor binding
zinc ion binding
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
protein deacetylase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
NAD-dependent protein deacetylase activity
histone acetyltransferase binding
histone deacetylase binding
tubulin deacetylase activity
ubiquitin binding
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
N-acetylcitrulline deacetylase activity
metal ion binding
NAD-dependent histone deacetylase activity (H4-K16 specific)
N-acetylgalactosamine-6-phosphate deacetylase activity
beta-tubulin binding
NAD binding
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
NAD+ binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0700004188.mm.1	TC0700000511.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0700004188.mm.1	NM_001122765.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0700004188.mm.1	NM_001122765.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0700004188.mm.1	NM_001122766.1.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0700004188.mm.1	NM_001122766.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0700004188.mm.1	NM_022432.4.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0700004188.mm.1	NM_022432.4	Refseq