Mm00456440_m1

• Gene Symbol: Adam17
• Gene Name: a disintegrin and metallopeptidase domain 17
• Gene Aliases: CD156b, Tace
• Chromosome Location: Chr.12: 21323509 - 21373632 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Adam17
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001277266.1	NP_001264195.1	17 - 18	2253		70
	NM_001291871.1	NP_001278800.1	16 - 17	2215		70
	NM_009615.6	NP_033745.4	16 - 17	2196		70
	NR_102380.1		13 - 14	1839		70
	NR_120376.1		16 - 17	2219		70
GenBank mRNA	AB021709.1	-	16 - 17	2157		70
	AJ007365.1	-	16 - 17	1996		70
	AK137183.1	-	8 - 9	3305		70
	AK137693.1	-	16 - 17	2103		70
	AK139471.1	-	16 - 17	2102		70
	AK142441.1	-	16 - 17	2155		70
	AK144161.1	-	17 - 18	2183		70
	AK149288.1	-	16 - 17	2099		70
	BC026052.1	-	13 - 14	1735		70
	BC048792.1	-	16 - 17	2103		70
	BC094655.1	-	16 - 17	2110	5705503	70
	BC114999.1	-	16 - 17	2056	6506501	70
	BC138416.1	-	16 - 17	2075	8861436	70
	BC138420.1	-	16 - 17	2075	8861440	70
	BC145270.1	-	16 - 17	2075	9053824	70
	U69613.1	-	16 - 17	2064		70
	U69614.1	-	16 - 17	2171		70

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1200001490.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Protease, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Adam17

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

response to hypoxia
positive regulation of protein phosphorylation
germinal center formation
proteolysis
membrane protein ectodomain proteolysis
cell adhesion
epidermal growth factor receptor signaling pathway
Notch signaling pathway
Notch receptor processing
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
B cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
response to lipopolysaccharide
positive regulation of chemokine production
regulation of mast cell apoptotic process
T cell differentiation in thymus
cell adhesion mediated by integrin
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
response to drug
negative regulation of apoptotic process
positive regulation of epidermal growth factor-activated receptor activity
spleen development
cell motility
defense response to Gram-positive bacterium
PMA-inducible membrane protein ectodomain proteolysis
positive regulation of cellular component movement
response to high density lipoprotein particle

Function(s)

metalloendopeptidase activity
Notch binding
interleukin-6 receptor binding
integrin binding
protein binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
SH3 domain binding
PDZ domain binding
metal ion binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1200010445.mm.1	NM_001277266.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1200010445.mm.1	NM_009615.6	Refseq
Affymetrix Mouse Clariom S Array	PSR1200010445.mm.1	NR_102380.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1200010445.mm.1	TC1200001490.mm.1	MTA TC