Mm00465141_m1

• Gene Symbol: Prkdc
• Gene Name: protein kinase, DNA activated, catalytic polypeptide
• Gene Aliases: AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
• Chromosome Location: Chr.16: 15637444 - 15842252 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Prkdc
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_011159.2	NP_035289.2	78 - 79	11196		58
GenBank mRNA	AB007544.1	-	78 - 79	11173		58
	AB011543.1	-	78 - 79	11185		58
	AK088981.1	-	3 - 4	323		58
	AK137732.1	-	5 - 6	631		58
	D83786.1	-	3 - 4	331		58
	D87521.1	-	78 - 79	11173		58

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1600000190.mm.1

• Set Membership: Ambion siRNA available, Amplicon length less than or equal to 70, Protein Kinase, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Prkdc

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

telomere maintenance
double-strand break repair via homologous recombination
somitogenesis
negative regulation of protein phosphorylation
B cell lineage commitment
pro-B cell differentiation
T cell lineage commitment
immunoglobulin production
negative regulation of immunoglobulin production
positive regulation of immune system process
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
protein phosphorylation
cellular response to DNA damage stimulus
brain development
heart development
intrinsic apoptotic signaling pathway in response to DNA damage
response to ionizing radiation
response to gamma radiation
phosphorylation
peptidyl-serine phosphorylation
lymphocyte differentiation
protein destabilization
cellular response to insulin stimulus
T cell differentiation in thymus
V(D)J recombination
immunoglobulin V(D)J recombination
T cell receptor V(D)J recombination
ectopic germ cell programmed cell death
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
rhythmic process
spleen development
thymus development
positive regulation of developmental growth
signal transduction involved in mitotic G1 DNA damage checkpoint
negative regulation of cellular senescence
negative regulation of response to gamma radiation

Function(s)

nucleotide binding
DNA binding
double-stranded DNA binding
protein kinase activity
protein serine/threonine kinase activity
DNA-dependent protein kinase activity
protein binding
ATP binding
transcription factor binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
enzyme binding
poly(A) RNA binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1600001476.mm.1	NM_011159.2.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1600001476.mm.1	NM_011159.2	Refseq
Affymetrix Mouse Clariom S Array	PSR1600001476.mm.1	TC1600000190.mm.1	MTA TC