Mm00476973_g1

• Gene Symbol: Pml
• Gene Name: promyelocytic leukemia
• Gene Aliases: 1200009E24Rik, AI661194, Trim19
• Chromosome Location: Chr.9: 58217179 - 58249796 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Pml
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_008884.5	NP_032910.3	5 - 6	1646		74
	NM_178087.4	NP_835188.2	6 - 7	1784		74
GenBank mRNA	AK028044.1	-	6 - 7	1786		74
	AK032799.1	-	4 - 5	664		74
	AK137538.1	-	6 - 7	1732		74
	AK156279.1	-	6 - 7	1944		74
	BC020990.1	-	6 - 7	1591	4188386	74
	KJ650238.1	-	6 - 7	1688		74
	U33626.2	-	5 - 6	1543		74

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0900002389.mm.1

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Mammalian Gene Collection, Detect Genomic DNA, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Pml

Gene Ontology Categories:

Process(es)

response to hypoxia
regulation of protein phosphorylation
positive regulation of defense response to virus by host
immune system process
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
protein targeting
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
SMAD protein import into nucleus
cell aging
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
response to UV
response to gamma radiation
regulation of calcium ion transport into cytosol
viral process
negative regulation of angiogenesis
myeloid cell differentiation
negative regulation of cell growth
PML body organization
positive regulation of histone deacetylation
negative regulation of telomere maintenance via telomerase
endoplasmic reticulum calcium ion homeostasis
circadian regulation of gene expression
negative regulation of translation in response to oxidative stress
response to cytokine
regulation of circadian rhythm
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
cell fate commitment
regulation of MHC class I biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
retinoic acid receptor signaling pathway
rhythmic process
negative regulation of interleukin-1 secretion
negative regulation of interleukin-1 beta secretion
protein stabilization
maintenance of protein location in nucleus
defense response to virus
negative regulation of telomerase activity
positive regulation of apoptotic process involved in mammary gland involution
branching involved in mammary gland duct morphogenesis
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to interleukin-4
intrinsic apoptotic signaling pathway by p53 class mediator
cellular senescence
extrinsic apoptotic signaling pathway
negative regulation of viral release from host cell
regulation of nucleic acid-templated transcription
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of double-strand break repair
positive regulation of apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

DNA binding
transcription coactivator activity
protein binding
zinc ion binding
ubiquitin protein ligase binding
SUMO binding
protein homodimerization activity
SMAD binding
metal ion binding
protein heterodimerization activity
cobalt ion binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0900020081.mm.1	NM_008884.5.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020081.mm.1	NM_008884.5	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020081.mm.1	NM_178087.4.1	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020081.mm.1	NM_178087.4	Refseq
Affymetrix Mouse Clariom S Array	PSR0900020081.mm.1	TC0900002389.mm.1	MTA TC