Mm00498779_m1

• Gene Symbol: Shank3
• Gene Name: SH3/ankyrin domain gene 3
• Gene Aliases: AI841104, SHANK3c-3, SHANK3c-4, Shank3b
• Chromosome Location: Chr.15: 89499707 - 89560261 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Shank3
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_021423.3	NP_067398.2	16 - 17	2032		76
GenBank mRNA	AB231013.1	-	16 - 17	2032		76
	AB841411.1	-	6 - 7	996		76
	AB841412.1	-	6 - 7	996		76
	AJ245904.1	-	14 - 15	1886		76

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1500000878.mm.1

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Shank3

Gene Ontology Categories:

Process(es)

MAPK cascade
embryonic epithelial tube formation
synapse assembly
learning
memory
striatal medium spiny neuron differentiation
adult behavior
negative regulation of actin filament bundle assembly
social behavior
locomotory exploration behavior
vocal learning
negative regulation of cell volume
positive regulation of long-term neuronal synaptic plasticity
brain morphogenesis
neuromuscular process controlling balance
protein oligomerization
positive regulation of synapse structural plasticity
positive regulation of synaptic transmission, glutamatergic
dendritic spine morphogenesis
positive regulation of dendritic spine development
regulation of dendritic spine morphogenesis
vocalization behavior
postsynaptic density assembly
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
guanylate kinase-associated protein clustering
regulation of long-term synaptic potentiation
positive regulation of long-term synaptic potentiation
positive regulation of glutamate receptor signaling pathway
regulation of long term synaptic depression
positive regulation of excitatory postsynaptic potential
regulation of grooming behavior
regulation of behavioral fear response
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Function(s)

actin binding
protein binding
protein C-terminus binding
zinc ion binding
SH3 domain binding
GKAP/Homer scaffold activity
ionotropic glutamate receptor binding
identical protein binding
protein self-association
scaffold protein binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1500006993.mm.1	NM_021423.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1500006993.mm.1	NM_021423.3	Refseq
Affymetrix Mouse Clariom S Array	PSR1500006993.mm.1	TC1500000878.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR1500007002.mm.1	NM_021423.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1500007002.mm.1	NM_021423.3	Refseq
Affymetrix Mouse Clariom S Array	PSR1500007002.mm.1	TC1500000878.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR1500006997.mm.1	NM_021423.3.1	Refseq
Affymetrix Mouse Clariom S Array	PSR1500006997.mm.1	NM_021423.3	Refseq
Affymetrix Mouse Clariom S Array	PSR1500006997.mm.1	TC1500000878.mm.1	MTA TC