C_104324165_10

• SNP ID: rs78357666
• Gene: HSP90AA1
• Gene Name: heat shock protein 90 alpha family class A member 1
• Set Membership: -
• Chromosome Location: Chr.14: 102097359 - 102097359 on Build GRCh38
• Polymorphism: T/A, Transversion substitution
• Context Sequence [VIC/FAM]:

  AAAGGAAAATTTGAAGCAAGCTGAG[T/A]CTTAAGGTAGAGAGAGCCAGGGATT

Assay Details

Species:	Human
dbSNP Submissions:	NA
Phenotype:	MIM: 140571
Literature Links:	HSP90AA1 PubMed Links
Allele Nomenclature:
Minor Allele Frequency:

1000Genome	Applied Biosystems^®	HapMap
Global A (0.02) (0.98)	Caucasian - Not Available	CEPH (CEU) - Not Available
EAS A (0.00) (1.00)	African American - Not Available	YRI (Yoruba) - Not Available
SAS A (0.02) (0.98)	Chinese - Not Available	CHB (Han Chinese) - Not Available
AFR A (0.00) (1.00)	Japanese - Not Available	JPT (Japanese) - Not Available
EUR A (0.06) (0.94)
AMR A (0.03) (0.97)

HSP90AA1 - heat shock protein 90 alpha family class A member 1
Transcript Accession	SNP Location	SNP Type	Observed Codons	Observed Amino Acid	Protein ID
NM_001017963.2		Intron			NP_001017963.2
NM_005348.3		Intron			NP_005339.3
XM_011536718.2		Intron			XP_011535020.1

More Information

Panther Classification:

Molecular Function -

Hsp90 family chaperone

Gene Ontology Categories:

Process(es)

G2/M transition of mitotic cell cycle
neuron migration
skeletal muscle contraction
mitochondrial transport
receptor-mediated endocytosis
response to unfolded protein
signal transduction
response to heat
response to cold
response to salt stress
positive regulation of lamellipodium assembly
cardiac muscle cell apoptotic process
peptidyl-tyrosine phosphorylation
regulation of protein ubiquitination
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
protein refolding
regulation of protein complex assembly
protein unfolding
response to estrogen
protein import into mitochondrial outer membrane
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
response to antibiotic
vascular endothelial growth factor receptor signaling pathway
protein stabilization
regulation of nitric-oxide synthase activity
chaperone-mediated protein complex assembly
positive regulation of cardiac muscle contraction
chaperone-mediated autophagy
regulation of cellular response to heat

Function(s)

nucleotide binding
UTP binding
CTP binding
mRNA binding
protein tyrosine kinase activity
protein binding
ATP binding
GTP binding
ATPase activity
sulfonylurea receptor binding
protein kinase binding
protein phosphatase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
ion channel binding
poly(A) RNA binding
GTPase binding
Rho GDP-dissociation inhibitor binding
unfolded protein binding