100418

• Gene Symbol: Eif2ak3
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 3
• Gene Aliases: AI427929, Pek, Perk
• Chromosome Location: Chr.6: 70844484 - 70905240 on Build GRCm38
• UniGene ID: Mm.247167
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Eif2ak3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010121.2	NP_034251.2	2, 3	633
GenBank mRNA	AF076681.1	-	2, 3	625
	BC054809.1	-	2, 3	645	6839221

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_031599, XM_006236624, XM_006236623, XM_008762977, AF096835.

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

skeletal system development
ossification
angiogenesis
chondrocyte development
translation
regulation of translation
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
ER overload response
response to unfolded protein
endoplasmic reticulum organization
lactation
positive regulation of signal transduction
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of gene expression
regulation of translational initiation by eIF2 alpha phosphorylation
phosphorylation
negative regulation of translation
peptidyl-serine phosphorylation
regulation of fatty acid metabolic process
calcium-mediated signaling
bone mineralization
endoplasmic reticulum unfolded protein response
pancreas development
endocrine pancreas development
negative regulation of myelination
negative regulation of translation in response to stress
positive regulation of protein binding
SREBP signaling pathway
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of transcription from RNA polymerase I promoter
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
protein homooligomerization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of protein localization to nucleus
negative regulation of translation in response to endoplasmic reticulum stress
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of glutathione biosynthetic process
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
enzyme binding
protein phosphatase binding
identical protein binding
Hsp90 protein binding
eukaryotic initiation factor eIF2 binding