101857

• Gene Symbol: Cd74
• Gene Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
• Gene Aliases: CLIP, DHLAG, HLADG, Ia-GAMMA, Ii
• Chromosome Location: Chr.18: 60803849 - 60812652 on Build GRCm38
• UniGene ID: Mm.439737
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Cd74
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001042605.1	NP_001036070.1	2, 3	330
	NM_010545.3	NP_034675.1	2, 3	330
GenBank mRNA	AK002232.1	-	2, 3	330
	AK020607.1	-	2, 3	331
	AK154096.1	-	2, 3	361
	BC003476.1	-	2, 3	330	2650401
	BC096435.1	-	2, 3	341	6530802
	X00496.1	-	1, 2	107

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_013069, XM_006254761, FQ233706, CB696567, FQ228116, and others.

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPK activity
prostaglandin biosynthetic process
positive regulation of cytokine-mediated signaling pathway
immune system process
positive regulation of dendritic cell antigen processing and presentation
negative regulation of peptide secretion
positive regulation of adaptive immune response
positive regulation of type 2 immune response
negative regulation of mature B cell apoptotic process
protein folding
protein complex assembly
intracellular protein transport
defense response
immune response
signal transduction
cell proliferation
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of B cell proliferation
macrophage migration inhibitory factor signaling pathway
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive thymic T cell selection
negative thymic T cell selection
positive regulation of innate immune response
negative regulation of T cell differentiation
positive regulation of T cell differentiation
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
chaperone mediated protein folding requiring cofactor
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of chemokine (C-X-C motif) ligand 2 production

Function(s)

beta-amyloid binding
cytokine receptor activity
protein binding
cytokine binding
MHC class II protein complex binding
macrophage migration inhibitory factor binding
MHC class II protein binding
MHC class II protein binding, via antigen binding groove
protein binding involved in protein folding
nitric-oxide synthase binding