103300 Validated

• Gene Symbol: TEK
• Gene Name: TEK receptor tyrosine kinase
• Gene Aliases: CD202B, TIE-2, TIE2, VMCM, VMCM1
• Chromosome Location: Chr.9: 27109141 - 27230178 on Build GRCh38
• UniGene ID: Hs.89640
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TEK
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000459.4	NP_000450.2	2	665
	NM_001290077.1	NP_001277006.1	2	665
	XM_005251561.1	XP_005251618.1	2	332
	XM_005251563.1	XP_005251620.1	2	332
GenBank mRNA	AB086825.1	-	2	321
	AB208796.1	-	2	343
	AK291775.1	-	2	353
	AK295043.1	-	2	391
	BC035514.1	-	2	340	5228999
	EU826591.1	-	2	215
	EU826592.1	-	2	215
	L06139.1	-	2	363

More Information

Matching Taqman Gene Expression Assay:

Hs00176096_m1

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
angiogenesis
response to hypoxia
positive regulation of protein phosphorylation
endothelial cell proliferation
positive regulation of endothelial cell proliferation
endochondral ossification
sprouting angiogenesis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell-cell signaling
heart development
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of angiogenesis
peptidyl-tyrosine phosphorylation
organ regeneration
regulation of establishment or maintenance of cell polarity
substrate adhesion-dependent cell spreading
negative regulation of apoptotic process
regulation of vascular permeability
response to peptide hormone
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of angiogenesis
protein autophosphorylation
Tie signaling pathway
negative regulation of inflammatory response
leukocyte migration
protein oligomerization
response to cAMP
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
definitive hemopoiesis
heart trabecula formation
positive regulation of ERK1 and ERK2 cascade
positive regulation of intracellular signal transduction
positive regulation of actin cytoskeleton reorganization
regulation of endothelial cell apoptotic process
negative regulation of endothelial cell apoptotic process

Function(s)

protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
growth factor binding