103428

• Gene Symbol: CHEK2
• Gene Name: checkpoint kinase 2
• Gene Aliases: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
• Chromosome Location: Chr.22: 28687743 - 28741866 on Build GRCh38
• UniGene ID: Hs.291363
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CHEK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005735.1	NP_001005735.1	4, 5	652
	NM_001257387.1	NP_001244316.1	3, 4	523
	NM_007194.3	NP_009125.1	3, 4	523
	NM_145862.2	NP_665861.1	3, 4	523
	XM_011529839.2	XP_011528141.1	4, 5	674
	XM_011529840.2	XP_011528142.1	4, 5	676
	XM_011529844.2	XP_011528146.1	4, 5	684
	XM_011529845.2	XP_011528147.1	2, 3	230
	XM_017028560.1	XP_016884049.1	4, 5	638
GenBank mRNA	AB040105.1	-	2, 3	451
	AF086904.1	-	2, 3	451
	AF096279.1	-	2, 3	451
	AF174135.1	-	2, 3	451
	AF217975.1	-	3, 4	1122
	AJ131197.1	-	2, 3	451
	AJ783839.1	-	2, 3	451
	AK289360.1	-	3, 4	502
	AK290754.1	-	3, 4	525
	AY551297.1	-	3, 4	580
	AY551298.1	-	2, 3	451
	AY551299.1	-	2, 3	451
	AY551300.1	-	2, 3	451
	AY551302.1	-	2, 3	451
	AY551305.1	-	2, 3	451
	BC004207.2	-	3, 4	478	3532866
	CR456418.1	-	4, 5	651

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
G2/M transition of mitotic cell cycle
replicative cell aging
positive regulation of protein phosphorylation
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
peptidyl-serine phosphorylation
cellular response to drug
regulation of protein catabolic process
signal transduction in response to DNA damage
cellular protein catabolic process
positive regulation of transcription, DNA-templated
protein autophosphorylation
protein stabilization
cell division
negative regulation of cell cycle arrest
signal transduction involved in intra-S DNA damage checkpoint
mitotic spindle assembly
replicative senescence
regulation of signal transduction by p53 class mediator
response to doxorubicin
cellular response to bisphenol A
negative regulation of DNA damage checkpoint
positive regulation of anoikis

Function(s)

protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding