103719

Gene Symbol:

AKT1 AKT2

Gene Name:

AKT serine/threonine kinase 1

AKT serine/threonine kinase 2

Gene Aliases:

AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA

HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA

Chromosome Location:

Chr.14: 104769349 - 104795743 on Build GRCh38

Chromosome Location:

Chr.19: 40230317 - 40285531 on Build GRCh38

UniGene ID:

Hs.525622

Hs.631535

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: AKT1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001014431.1	NP_001014431.1	11	1473
	NM_001014432.1	NP_001014432.1	12	1557
	NM_005163.2	NP_005154.2	11	1687
	XM_005267401.1	XP_005267458.1	11	1622
	XM_017021075.1	XP_016876564.1	12	1800
	XM_017021076.1	XP_016876565.1	12	1706
	XM_017021077.1	XP_016876566.1	11	1622
	XM_017021078.1	XP_016876567.1	12	1333
GenBank mRNA	AB451242.1	-	10	1133
	AB451367.1	-	10	1133
	AK122894.1	-	11	2614
	AK131465.1	-	1	47
	AK299310.1	-	9	1077
	AK314256.1	-	11	1286
	BC000479.2	-	11	1408	2964603
	BC001737.1	-	2	296
	BC084538.1	-	12	1551	6645486
	BX647722.1	-	2	5580
	BX648205.1	-	10	2091
	KU177898.1	-	10	1133
	M63167.1	-	11	1331
	X61037.1	-	8	944

Gene Symbol: AKT2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	KU159425.1	-	11	1382

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
osteoblast differentiation
maternal placenta development
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
glycogen biosynthetic process
regulation of glycogen biosynthetic process
glucose metabolic process
translation
regulation of translation
cellular protein modification process
protein phosphorylation
negative regulation of protein kinase activity
nitric oxide biosynthetic process
activation-induced cell death of T cells
inflammatory response
cellular response to DNA damage stimulus
response to oxidative stress
signal transduction
G-protein coupled receptor signaling pathway
germ cell development
aging
cell proliferation
insulin receptor signaling pathway
apoptotic mitochondrial changes
response to heat
negative regulation of autophagy
negative regulation of gene expression
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of fibroblast migration
positive regulation of sodium ion transport
positive regulation of glucose metabolic process
negative regulation of endopeptidase activity
regulation of neuron projection development
regulation of phosphatidylinositol 3-kinase signaling
glucose transport
phosphorylation
protein ubiquitination
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
spinal cord development
cell projection organization
cell differentiation
protein catabolic process
platelet activation
hyaluronan metabolic process
positive regulation of cell growth
regulation of cell migration
endocrine pancreas development
T cell costimulation
regulation of myelination
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
lipopolysaccharide-mediated signaling pathway
negative regulation of fatty acid beta-oxidation
positive regulation of endodeoxyribonuclease activity
response to food
positive regulation of cellular protein metabolic process
peripheral nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
positive regulation of peptidyl-serine phosphorylation
response to fluid shear stress
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
ERBB2 signaling pathway
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of mRNA stability
protein kinase B signaling
positive regulation of blood vessel endothelial cell migration
positive regulation of nitric oxide biosynthetic process
positive regulation of fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of epidermal growth factor receptor signaling pathway
negative regulation of cell size
negative regulation of proteolysis
positive regulation of vasoconstriction
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
negative regulation of JNK cascade
protein autophosphorylation
positive regulation of lipid biosynthetic process
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
regulation of nitric-oxide synthase activity
positive regulation of nitric-oxide synthase activity
positive regulation of sequence-specific DNA binding transcription factor activity
striated muscle cell differentiation
response to growth hormone
mammary gland epithelial cell differentiation
glycogen cell differentiation involved in embryonic placenta development
labyrinthine layer blood vessel development
response to UV-A
cellular response to mechanical stimulus
cellular response to epidermal growth factor stimulus
cellular response to prostaglandin E stimulus
cellular response to organic cyclic compound
cellular response to hypoxia
establishment of protein localization to mitochondrion
maintenance of protein location in mitochondrion
positive regulation of establishment of protein localization to plasma membrane
negative regulation of release of cytochrome c from mitochondria
cellular response to granulocyte macrophage colony-stimulating factor stimulus
execution phase of apoptosis
chemical synaptic transmission, postsynaptic
negative regulation of protein kinase activity by protein phosphorylation
positive regulation of protein localization to nucleus
negative regulation of neuron death
regulation of signal transduction by p53 class mediator
regulation of cell cycle checkpoint
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
cellular response to nerve growth factor stimulus
response to insulin-like growth factor stimulus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein kinase C binding
protein binding
ATP binding
phosphatidylinositol-3,4,5-trisphosphate binding
kinase activity
enzyme binding
nitric-oxide synthase regulator activity
GTPase activating protein binding
identical protein binding
phosphatidylinositol-3,4-bisphosphate binding
protein phosphatase 2A binding
14-3-3 protein binding