103966 Validated

• Gene Symbol: PCSK9
• Gene Name: proprotein convertase subtilisin/kexin type 9
• Gene Aliases: FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
• Chromosome Location: Chr.1: 55039476 - 55064853 on Build GRCh38
• UniGene ID: Hs.18844
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PCSK9
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_174936.3	NP_777596.2	8, 9	1724
GenBank mRNA	AK075365.1	-	8, 9	1653
	AK122717.1	-	9, 10	1409
	AK124635.1	-	5, 6	2086
	EF692496.1	-	8, 9	1362

More Information

Matching Taqman Gene Expression Assay:

Hs00545399_m1

Panther Classification:

Molecular Function -

serine protease

Gene Ontology Categories:

Process(es)

kidney development
liver development
negative regulation of receptor recycling
positive regulation of receptor internalization
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
cholesterol metabolic process
cellular response to starvation
regulation of receptor activity
negative regulation of low-density lipoprotein particle clearance
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity

Function(s)

serine-type endopeptidase activity
protein binding
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
poly(A) RNA binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding