105004

• Gene Symbol: PSEN1
• Gene Name: presenilin 1
• Gene Aliases: AD3, FAD, PS-1, PS1, S182
• Chromosome Location: Chr.14: 73136435 - 73223691 on Build GRCh38
• UniGene ID: Hs.3260
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PSEN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000021.3	NP_000012.1	8	1088
	NM_007318.2	NP_015557.2	8	1076
	XM_005267864.2	XP_005267921.1	8	1082
	XM_005267866.1	XP_005267923.1	8	1071
	XM_011536971.2	XP_011535273.1	8	980
	XM_011536972.2	XP_011535274.1	8	1344
	XM_011536973.1	XP_011535275.1	8	1332
	XM_011536974.1	XP_011535276.1	8	973
GenBank mRNA	AF416717.1	-	6	804
	AK122722.1	-	6	2357
	AK223173.1	-	6	818
	AK312531.1	-	8	1072
	BC011729.2	-	8	1057	4423098
	KU178285.1	-	6	792
	KU178286.1	-	6	804
	L42110.1	-	8	1052
	L76517.1	-	8	1345
	U40379.1	-	6	792
	U40380.1	-	6	792

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019163, XM_006240321, XM_006240322, D82363, BC070887, and others.

Panther Classification:

Molecular Function -

aspartic protease

Gene Ontology Categories:

Process(es)

autophagosome assembly
negative regulation of transcription from RNA polymerase II promoter
activation of MAPKK activity
blood vessel development
cell fate specification
somitogenesis
neuron migration
positive regulation of receptor recycling
heart looping
hematopoietic progenitor cell differentiation
T cell activation involved in immune response
neural retina development
protein glycosylation
membrane protein ectodomain proteolysis
mitochondrial transport
cellular response to DNA damage stimulus
response to oxidative stress
negative regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
Notch receptor processing
memory
post-embryonic development
protein transport
L-glutamate transport
choline transport
synaptic vesicle targeting
single organismal cell-cell adhesion
protein processing
cerebral cortex cell migration
Cajal-Retzius cell differentiation
dorsal/ventral neural tube patterning
embryonic limb morphogenesis
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
endoplasmic reticulum calcium ion homeostasis
beta-amyloid formation
intracellular signal transduction
regulation of phosphorylation
amyloid precursor protein catabolic process
myeloid dendritic cell differentiation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of catalytic activity
regulation of protein binding
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
skin morphogenesis
positive regulation of transcription, DNA-templated
regulation of synaptic plasticity
thymus development
neuron development
skeletal system morphogenesis
brain morphogenesis
epithelial cell proliferation
negative regulation of axonogenesis
positive regulation of coagulation
T cell receptor signaling pathway
neuron apoptotic process
negative regulation of ubiquitin-protein transferase activity
smooth endoplasmic reticulum calcium ion homeostasis
regulation of synaptic transmission, glutamatergic
canonical Wnt signaling pathway
regulation of resting membrane potential
positive regulation of dendritic spine development
calcium ion transmembrane transport
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic signaling pathway

Function(s)

endopeptidase activity
aspartic-type endopeptidase activity
calcium channel activity
protein binding
beta-catenin binding
PDZ domain binding
cadherin binding