105912

• Gene Symbol: PTPN6
• Gene Name: protein tyrosine phosphatase, non-receptor type 6
• Gene Aliases: HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
• Chromosome Location: Chr.12: 6946576 - 6961316 on Build GRCh38
• UniGene ID: Hs.63489
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PTPN6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002831.5	NP_002822.2	6	949
	NM_080548.4	NP_536858.1	6	862
	NM_080549.3	NP_536859.1	6	949
	XM_006718994.1	XP_006719057.1	6	1006
	XM_011520988.1	XP_011519290.1	6	863
GenBank mRNA	AF178946.1	-	6	731
	AK223629.1	-	6	844
	AK290421.1	-	6	832
	AK298470.1	-	5	1115
	AK300167.1	-	5	706
	AK308230.1	-	6	897
	AK313379.1	-	6	862
	BC002523.2	-	6	848	3140265
	BC007667.2	-	6	848	3138804
	BT007390.1	-	5	713
	M74903.1	-	6	790
	M77273.1	-	6	851

More Information

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

hematopoietic progenitor cell differentiation
negative regulation of humoral immune response mediated by circulating immunoglobulin
protein dephosphorylation
apoptotic process
G-protein coupled receptor signaling pathway
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cell differentiation
platelet activation
platelet formation
T cell costimulation
abortive mitotic cell cycle
positive regulation of cell adhesion mediated by integrin
peptidyl-tyrosine dephosphorylation
intracellular signal transduction
megakaryocyte development
negative regulation of T cell proliferation
natural killer cell mediated cytotoxicity
negative regulation of MAP kinase activity
regulation of B cell differentiation
negative regulation of peptidyl-tyrosine phosphorylation
B cell receptor signaling pathway
negative regulation of B cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
leukocyte migration
regulation of release of sequestered calcium ion into cytosol
regulation of type I interferon-mediated signaling pathway
regulation of ERK1 and ERK2 cascade
platelet aggregation
regulation of G1/S transition of mitotic cell cycle

Function(s)

phosphotyrosine binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
protein binding
SH3 domain binding
protein kinase binding
SH2 domain binding