106443

• Gene Symbol: EP300
• Gene Name: E1A binding protein p300
• Gene Aliases: KAT3B, RSTS2, p300
• Chromosome Location: Chr.22: 41092610 - 41180077 on Build GRCh38
• UniGene ID: Hs.517517
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: EP300
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001429.3	NP_001420.2	2	944
	XM_006724165.3	XP_006724228.1	2	644
GenBank mRNA	BC053889.1	-	2	912
	U01877.1	-	2	1748

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008765878, AB066220.
This siRNA also targets the following transcripts in Mouse: NM_177821, AK042627, BC150681, BC144976.

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
somitogenesis
liver development
positive regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
transcription-coupled nucleotide-excision repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein acetylation
internal protein amino acid acetylation
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
Notch signaling pathway
nervous system development
heart development
skeletal muscle tissue development
memory
circadian rhythm
organ morphogenesis
regulation of autophagy
positive regulation of glycoprotein biosynthetic process
macrophage derived foam cell differentiation
positive regulation of cell death
positive regulation of muscle atrophy
viral process
N-terminal peptidyl-lysine acetylation
internal peptidyl-lysine acetylation
B cell differentiation
platelet formation
lung development
response to cobalt ion
positive regulation of protein binding
positive regulation of type I interferon production
positive regulation of collagen biosynthetic process
positive regulation of protein import into nucleus, translocation
response to tumor necrosis factor
cellular response to UV
positive regulation of histone acetylation
cellular response to drug
megakaryocyte development
cellular response to trichostatin A
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of DNA binding
protein kinase B signaling
response to estrogen
positive regulation by host of viral transcription
histone H3 acetylation
histone H4 acetylation
histone H2B acetylation
fat cell differentiation
response to ethanol
positive regulation of translation
positive regulation of axon extension
positive regulation of cell size
positive regulation of gene expression, epigenetic
positive regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
positive regulation of protein secretion
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
response to calcium ion
regulation of cell cycle
regulation of angiotensin metabolic process
positive regulation of sarcomere organization
regulation of androgen receptor signaling pathway
regulation of transcription from RNA polymerase II promoter in response to hypoxia
protein-DNA complex assembly
cellular response to hydrogen peroxide
response to fatty acid
cellular response to retinoic acid
cellular response to cAMP
cellular response to glucose stimulus
cellular response to mineralocorticoid stimulus
cellular response to dexamethasone stimulus
regulation of tubulin deacetylation
regulation of cellular response to heat
regulation of signal transduction by p53 class mediator
beta-catenin-TCF complex assembly
cellular response to nerve growth factor stimulus
negative regulation of miRNA metabolic process

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
core promoter binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
transcription coactivator activity
histone acetyltransferase activity
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
protein binding
beta-catenin binding
protein C-terminus binding
transcription factor binding
zinc ion binding
acetyltransferase activity
transferase activity, transferring acyl groups
chromatin DNA binding
protein complex binding
activating transcription factor binding
peptide N-acetyltransferase activity
nuclear hormone receptor binding
glucocorticoid receptor binding
peroxisome proliferator activated receptor binding
bHLH transcription factor binding
SMAD binding
androgen receptor binding
mitogen-activated protein kinase binding
NF-kappaB binding
pre-mRNA intronic binding
protein antigen binding