106970 Validated

• Gene Symbol: SORL1
• Gene Name: sortilin related receptor 1
• Gene Aliases: C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250
• Chromosome Location: Chr.11: 121452203 - 121633762 on Build GRCh38
• UniGene ID: Hs.368592
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SORL1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003105.5	NP_003096.1	43, 44	6020
GenBank mRNA	AK294404.1	-	14, 15	2158
	AK295090.1	-	20, 21	2810
	AK295878.1	-	23, 24	2961
	AK302589.1	-	20, 21	2632
	AK316340.1	-	14, 15	1740
	BC137171.1	-	43, 44	5943	9021168
	Y08110.1	-	43, 44	5971

More Information

Matching Taqman Gene Expression Assay:

Hs00268342_m1

Panther Classification:

Molecular Function -

membrane traffic protein

Gene Ontology Categories:

Process(es)

protein targeting to Golgi
protein targeting
protein targeting to lysosome
lipid transport
post-Golgi vesicle-mediated transport
receptor-mediated endocytosis
signal transduction
cholesterol metabolic process
regulation of smooth muscle cell migration
negative regulation of protein binding
negative regulation of protein oligomerization
negative regulation of MAP kinase activity
protein retention in Golgi apparatus
positive regulation of protein catabolic process
negative regulation of neurogenesis
protein maturation
positive regulation of protein exit from endoplasmic reticulum
negative regulation of neuron death
negative regulation of beta-amyloid formation
positive regulation of choline O-acetyltransferase activity
negative regulation of tau-protein kinase activity
positive regulation of ER to Golgi vesicle-mediated transport
positive regulation of early endosome to recycling endosome transport
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of protein localization to early endosome
negative regulation of neurofibrillary tangle assembly
positive regulation of endocytic recycling

Function(s)

beta-amyloid binding
transmembrane signaling receptor activity
protein binding
low-density lipoprotein particle binding
ADP-ribosylation factor binding