107530

• Gene Symbol: SLIT2
• Gene Name: slit guidance ligand 2
• Gene Aliases: SLIL3, Slit-2
• Chromosome Location: Chr.4: 20251905 - 20620561 on Build GRCh38
• UniGene ID: Hs.29802
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SLIT2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001289135.2	NP_001276064.1	14, 15	3369
	NM_001289136.2	NP_001276065.1	14, 15	3357
	NM_004787.3	NP_004778.1	15, 16	3381
	XM_005248211.3	XP_005248268.1	15, 16	3393
	XM_006713986.3	XP_006714049.1	15, 16	3393
	XM_011513909.2	XP_011512211.1	15, 16	1421
	XM_011513910.2	XP_011512212.2	3, 4	2273
	XM_017008845.1	XP_016864334.1	15, 16	1408
GenBank mRNA	AB017168.1	-	15, 16	1674
	AF055585.1	-	14, 15	2002
	AF133270.1	-	14, 15	1458
	AK308444.1	-	3, 4	342
	BC117190.1	-	15, 16	1549	40125741
	BC143978.1	-	14, 15	1525	9052496

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_022632, XM_008770210.
This siRNA also targets the following transcripts in Mouse: NM_001291228, NM_178804, NM_001291227, AK220505, BC145487, and others.

Panther Classification:

Molecular Function -

immunoglobulin superfamily cell adhesion molecule

Gene Ontology Categories:

Process(es)

ureteric bud development
negative regulation of protein phosphorylation
cell migration involved in sprouting angiogenesis
negative regulation of leukocyte chemotaxis
axon guidance
motor neuron axon guidance
negative regulation of lamellipodium assembly
negative regulation of endothelial cell migration
negative regulation of smooth muscle cell migration
spinal cord development
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
chemorepulsion involved in postnatal olfactory bulb interneuron migration
corticospinal neuron axon guidance through spinal cord
negative regulation of cell growth
negative regulation of cell migration
negative regulation of actin filament polymerization
retinal ganglion cell axon guidance
response to nutrient levels
cellular response to hormone stimulus
negative regulation of GTPase activity
Roundabout signaling pathway
positive regulation of apoptotic process
negative regulation of vascular permeability
branching morphogenesis of an epithelial tube
axon extension involved in axon guidance
negative regulation of inflammatory response
positive regulation of axonogenesis
negative chemotaxis
induction of negative chemotaxis
negative regulation of small GTPase mediated signal transduction
response to cortisol
apoptotic process involved in luteolysis
negative regulation of chemokine-mediated signaling pathway
cellular response to heparin
negative regulation of smooth muscle cell chemotaxis
negative regulation of mononuclear cell migration
negative regulation of neutrophil chemotaxis
negative regulation of monocyte chemotaxis
negative regulation of retinal ganglion cell axon guidance
negative regulation of cellular response to growth factor stimulus

Function(s)

GTPase inhibitor activity
calcium ion binding
protein binding
heparin binding
identical protein binding
protein homodimerization activity
laminin-1 binding
proteoglycan binding
heparan sulfate proteoglycan binding
Roundabout binding