11010

• Gene Symbol: FMR1
• Gene Name: fragile X mental retardation 1
• Gene Aliases: FMRP, FRAXA, POF, POF1
• Chromosome Location: Chr.X: 147911951 - 147951127 on Build GRCh38
• UniGene ID: Hs.103183
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: FMR1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001185075.1	NP_001172004.1	4, 5	501
	NM_001185076.1	NP_001172005.1	4, 5	501
	NM_001185081.1	NP_001172010.1	4, 5	501
	NM_001185082.1	NP_001172011.1	4, 5	501
	NM_002024.5	NP_002015.1	4, 5	501
	NR_033699.1		4, 5	501
	NR_033700.1		4, 5	501
GenBank mRNA	BC038998.1	-	4, 5	466
	BC086957.1	-	4, 5	531	30347992
	BQ213316.1	-	4, 5	453
	KC774027.1	-	4, 5	334
	KC774028.1	-	4, 5	334
	KC774029.1	-	4, 5	334
	KF856234.1	-	4, 5	334
	KJ534836.1	-	4, 5	272
	KJ534837.1	-	4, 5	272
	KJ534838.1	-	4, 5	272
	KM091457.1	-	4, 5	334
	KM091458.1	-	4, 5	334
	KM091459.1	-	4, 5	334
	M67468.1	-	4, 5	467
	S65791.1	-	4, 5	491
	X69962.1	-	4, 5	491

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_052804, XM_006229530, XM_006229531, XM_006229535, XM_008773597, and others.
This siRNA also targets the following transcripts in Mouse: NM_008031, NM_001290424, AK053701, AK080948, AK053211, and others.

Panther Classification:

Molecular Function -

translation factor

Gene Ontology Categories:

Process(es)

regulation of alternative mRNA splicing, via spliceosome
positive regulation of receptor internalization
mRNA processing
cellular response to DNA damage stimulus
glutamate receptor signaling pathway
RNA splicing
negative regulation of translation
gene silencing by RNA
positive regulation of histone phosphorylation
cellular response to UV
regulation of mRNA stability
modulation by host of viral RNA genome replication
positive regulation of translation
negative regulation of translational initiation
regulation of neurotransmitter secretion
mRNA transport
regulation of filopodium assembly
positive regulation of filopodium assembly
regulation of gene silencing by miRNA
regulation of dendritic spine development
positive regulation of dendritic spine development
cellular response to hydroxyurea
cellular response to virus
regulation of neuronal action potential
negative regulation of long term synaptic depression
positive regulation of intracellular transport of viral material
negative regulation of voltage-gated calcium channel activity
positive regulation of proteasomal protein catabolic process
positive regulation of mRNA binding
negative regulation of synaptic vesicle exocytosis
positive regulation of gene silencing by miRNA
negative regulation of cytoplasmic translation
positive regulation of response to DNA damage stimulus

Function(s)

G-quadruplex RNA binding
chromatin binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
protein binding
microtubule binding
poly(U) RNA binding
translation repressor activity
translation initiation factor binding
RNA strand annealing activity
poly(G) binding
methylated histone binding
siRNA binding
miRNA binding
RNA stem-loop binding
identical protein binding
protein homodimerization activity
ribosome binding
ion channel binding
poly(A) RNA binding
dynein binding
protein heterodimerization activity
mRNA 5'-UTR binding
sequence-specific mRNA binding