110742 Validated

• Gene Symbol: HMGCR
• Gene Name: 3-hydroxy-3-methylglutaryl-CoA reductase
• Gene Aliases: LDLCQ3
• Chromosome Location: Chr.5: 75336334 - 75362101 on Build GRCh38
• UniGene ID: Hs.628096
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HMGCR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000859.2	NP_000850.1	5	577
	NM_001130996.1	NP_001124468.1	5	577
	XM_011543357.1	XP_011541659.1	5	728
	XM_011543358.1	XP_011541660.1	5	615
	XM_011543359.1	XP_011541661.1	5	728
GenBank mRNA	AK292892.1	-	5	508
	AK296499.1	-	5	732
	AK312437.1	-	4	421
	AY429542.1	-	1	32
	BC033692.1	-	5	513	5212903
	M11058.1	-	5	471

More Information

Matching Taqman Gene Expression Assay:

Hs00168352_m1

Panther Classification:

Molecular Function -

oxidoreductase, reductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

cholesterol biosynthetic process
ubiquinone metabolic process
aging
response to nutrient
isoprenoid biosynthetic process
visual learning
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
coenzyme A metabolic process
positive regulation of stress-activated MAPK cascade
negative regulation of MAP kinase activity
myoblast differentiation
response to ethanol
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade

Function(s)

hydroxymethylglutaryl-CoA reductase (NADPH) activity
protein binding
hydroxymethylglutaryl-CoA reductase activity
protein homodimerization activity
coenzyme binding
protein phosphatase 2A binding
NADPH binding