110845 Validated

• Gene Symbol: TOP2B
• Gene Name: topoisomerase (DNA) II beta
• Gene Aliases: TOPIIB, top2beta
• Chromosome Location: Chr.3: 25597905 - 25664936 on Build GRCh38
• UniGene ID: Hs.475733
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TOP2B
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001068.3	NP_001059.2	18	2234
	XM_005265427.3	XP_005265484.1	18	2813
	XM_011534057.2	XP_011532359.1	18	2223
GenBank mRNA	AB208879.1	-	15	1792
	AK296510.1	-	19	2289
	AK307450.1	-	20	2234
	M27504.1	-	14	1730
	X68060.1	-	18	2159
	Z15115.1	-	4	389

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001100858, AB262979.
This siRNA also targets the following transcripts in Mouse: NM_009409, BC054541, D38046, BC041106.

Matching Taqman Gene Expression Assay:

Hs00172259_m1

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

resolution of meiotic recombination intermediates
sister chromatid segregation
neuron migration
DNA topological change
DNA unwinding involved in DNA replication
mitotic recombination
axonogenesis
protein sumoylation
forebrain development
mitotic DNA integrity checkpoint

Function(s)

chromatin binding
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
ATP binding
protein C-terminus binding
DNA binding, bending
enzyme binding
histone deacetylase binding
metal ion binding
protein heterodimerization activity