111005

• Gene Symbol: PARP1
• Gene Name: poly(ADP-ribose) polymerase 1
• Gene Aliases: ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
• Chromosome Location: Chr.1: 226360691 - 226408100 on Build GRCh38
• UniGene ID: Hs.177766
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PARP1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001618.3	NP_001609.2	23	3349
GenBank mRNA	AK125650.1	-	8	3133
	AK225654.1	-	23	3314
	AK303340.1	-	23	3276
	BC037545.1	-	23	3322	5193735
	J03473.1	-	23	3273
	M18112.1	-	23	3317
	M32721.1	-	23	3337

More Information

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
double-strand break repair via homologous recombination
lagging strand elongation
DNA repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
double-strand break repair
transcription from RNA polymerase II promoter
protein ADP-ribosylation
cellular response to DNA damage stimulus
mitochondrion organization
transforming growth factor beta receptor signaling pathway
positive regulation of cardiac muscle hypertrophy
protein autoprocessing
protein sumoylation
signal transduction involved in regulation of gene expression
macrophage differentiation
mitochondrial DNA metabolic process
cellular response to insulin stimulus
nucleotide-excision repair, DNA incision
cellular response to oxidative stress
protein modification process
DNA damage response, detection of DNA damage
mitochondrial DNA repair
positive regulation of transcription from RNA polymerase II promoter
DNA ligation involved in DNA repair
positive regulation of SMAD protein import into nucleus
protein poly-ADP-ribosylation
global genome nucleotide-excision repair
regulation of cellular protein localization
negative regulation of telomere maintenance via telomere lengthening
ATP generation from poly-ADP-D-ribose
positive regulation of transcription regulatory region DNA binding

Function(s)

DNA binding
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity
protein binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
identical protein binding
histone deacetylase binding
poly(A) RNA binding
protein N-terminus binding
NAD binding
R-SMAD binding