111607

• Gene Symbol: TOPORS
• Gene Name: TOP1 binding arginine/serine rich protein
• Gene Aliases: LUN, P53BP3, RP31, TP53BPL
• Chromosome Location: Chr.9: 32540544 - 32552628 on Build GRCh38
• UniGene ID: Hs.589962
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TOPORS
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001195622.1	NP_001182551.1	2	249
	NM_005802.4	NP_005793.2	3	444
GenBank mRNA	AB045732.1	-	3	371
	AB045733.1	-	2	176
	AF098300.1	-	3	371
	AU280552.1	-	3	419
	BC060884.1	-	3	384	30344728
	DA238762.1	-	3	445
	U82939.1	-	2	102

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001108658.
This siRNA also targets the following transcripts in Mouse: NM_134097, AB104865, AK153743, AB072395, AK143025, and others.

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

protein polyubiquitination
transcription, DNA-templated
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
retina layer formation
protein sumoylation
protein localization to nucleus
photoreceptor cell outer segment organization
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
retinal rod cell development
retinal cone cell development
positive regulation of ubiquitin-protein transferase activity
maintenance of protein location in nucleus
protein K48-linked ubiquitination

Function(s)

DNA binding
antigen binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
SUMO transferase activity
DNA topoisomerase binding
ubiquitin protein ligase activity