112281

• Gene Symbol: HAVCR2
• Gene Name: hepatitis A virus cellular receptor 2
• Gene Aliases: CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
• Chromosome Location: Chr.5: 157085832 - 157109237 on Build GRCh38
• UniGene ID: Hs.710500
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HAVCR2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_032782.4	NP_116171.3	7	1534
GenBank mRNA	AF251707.1	-	7	1406
	AK027334.1	-	7	1323
	AK130144.1	-	5	831
	BC063431.1	-	7	1424	5229539

More Information

Panther Classification:

Molecular Function -

immunoglobulin receptor superfamily

Gene Ontology Categories:

Process(es)

adaptive immune response
macrophage activation involved in immune response
natural killer cell tolerance induction
regulation of tolerance induction dependent upon immune response
negative regulation of T-helper 1 type immune response
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
inflammatory response
negative regulation of gene expression
negative regulation of myeloid dendritic cell activation
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-alpha production
negative regulation of interferon-gamma production
negative regulation of interleukin-2 production
negative regulation of interleukin-3 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 production
positive regulation of interleukin-4 production
negative regulation of natural killer cell activation
toll-like receptor 3 signaling pathway
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of macrophage activation
innate immune response
defense response to Gram-positive bacterium
maternal process involved in female pregnancy
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
negative regulation of granulocyte colony-stimulating factor production
negative regulation of defense response to bacterium
positive regulation of defense response to bacterium
positive regulation of NIK/NF-kappaB signaling
positive regulation of tumor necrosis factor secretion
negative regulation of immunological synapse formation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Function(s)

protein binding
metal ion binding