11334

• Gene Symbol: LIF
• Gene Name: leukemia inhibitory factor
• Gene Aliases: CDF, DIA, HILDA, MLPLI
• Chromosome Location: Chr.22: 30240447 - 30246851 on Build GRCh38
• UniGene ID: Hs.2250
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: LIF
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001257135.1	NP_001244064.1	2	510
	NM_002309.4	NP_002300.1	3	689
GenBank mRNA	AK315310.1	-	3	637
	BC069540.1	-	3	583	7262225
	BC093733.1	-	3	581	7939578
	BC093735.1	-	3	581	7939580
	BC143305.1	-	2	402
	X13967.1	-	3	577

More Information

Panther Classification:

Molecular Function -

cytokine, intercellular signal molecule

Gene Ontology Categories:

Process(es)

blood vessel remodeling
immune response
multicellular organism development
embryo implantation
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of neuron projection development
negative regulation of angiogenesis
stem cell population maintenance
organ regeneration
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-serine phosphorylation of STAT protein
tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
positive regulation of macrophage differentiation
negative regulation of meiotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
decidualization
negative regulation of hormone secretion
lung alveolus development
muscle organ morphogenesis
neuron development
astrocyte differentiation
positive regulation of astrocyte differentiation
leukemia inhibitory factor signaling pathway
stem cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of corticotropin secretion
retina development in camera-type eye
transdifferentiation
lung vasculature development
lung lobe morphogenesis
trophoblast giant cell differentiation
spongiotrophoblast differentiation
negative regulation of ERK1 and ERK2 cascade
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
positive regulation of protein localization to nucleus
positive regulation of histone H3-K27 acetylation
regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Function(s)

transcription factor activity, RNA polymerase II transcription factor recruiting
receptor binding
cytokine activity
leukemia inhibitory factor receptor binding
protein binding
growth factor activity