114443

• Gene Symbol: SREBF2
• Gene Name: sterol regulatory element binding transcription factor 2
• Gene Aliases: SREBP-2, SREBP2, bHLHd2
• Chromosome Location: Chr.22: 41833079 - 41907308 on Build GRCh38
• UniGene ID: Hs.443258
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SREBF2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_004599.3	NP_004590.2	2	701
	NR_103834.1		2	701
	XM_006724310.2	XP_006724373.1	2	945
	XM_011530347.1	XP_011528649.1	2	530
	XM_017028921.1	XP_016884410.1	2	530
	XM_017028922.1	XP_016884411.1	2	530
GenBank mRNA	AK299914.1	-	2	530
	BC051385.1	-	2	616	5497929
	BC051799.1	-	2	667
	BC056158.1	-	2	647	6169568
	CT841522.1	-	2	591
	U02031.1	-	2	626

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001033694, XM_006242079, BC101902.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
lipid metabolic process
cholesterol metabolic process
cellular response to starvation
positive regulation of cholesterol storage
positive regulation of transcription from RNA polymerase II promoter
response to low-density lipoprotein particle
cellular response to laminar fluid shear stress
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of cholesterol efflux
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
regulation of cholesterol homeostasis

Function(s)

C-8 sterol isomerase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein C-terminus binding
protein dimerization activity
E-box binding