115568

• Gene Symbol: MED1
• Gene Name: mediator complex subunit 1
• Gene Aliases: CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
• Chromosome Location: Chr.17: 39404285 - 39451281 on Build GRCh38
• UniGene ID: Hs.643754
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MED1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_004774.3	NP_004765.2	5	531
	XM_006721957.1	XP_006722020.1	5	528
	XM_017024779.1	XP_016880268.1	5	538
GenBank mRNA	AF055994.1	-	5	511
	AF283812.1	-	4	274
	AK314185.1	-	5	528
	BC006517.2	-	5	504
	BC060758.1	-	5	509
	BC131783.1	-	5	385	40125129
	BP357374.1	-	5	531
	Y13467.1	-	5	509

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001134361, XM_006247398, XM_008768105, XM_006247399, XM_006247401.
This siRNA also targets the following transcripts in Mouse: NM_013634, NM_134027, NM_001080118, AF000294, AK054437, and others.

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
angiogenesis
liver development
embryonic placenta development
lens development in camera-type eye
thyroid hormone mediated signaling pathway
ventricular trabecula myocardium morphogenesis
retinal pigment epithelium development
regulation of transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase II promoter
thyroid hormone generation
androgen biosynthetic process
brain development
lactation
positive regulation of gene expression
negative regulation of keratinocyte proliferation
protein ubiquitination
keratinocyte differentiation
monocyte differentiation
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
organ regeneration
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of protein import into nucleus, translocation
positive regulation of mammary gland epithelial cell proliferation
embryonic heart tube development
embryonic hindlimb morphogenesis
embryonic hemopoiesis
peroxisome proliferator activated receptor signaling pathway
cellular response to hepatocyte growth factor stimulus
megakaryocyte development
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
cellular lipid metabolic process
fat cell differentiation
positive regulation of keratinocyte differentiation
positive regulation of erythrocyte differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
erythrocyte development
enucleate erythrocyte development
regulation of cell cycle
positive regulation of interferon-gamma-mediated signaling pathway
mammary gland branching involved in thelarche
mammary gland branching involved in pregnancy
epithelial cell proliferation involved in mammary gland duct elongation
positive regulation of G0 to G1 transition
ERK1 and ERK2 cascade
regulation of vitamin D receptor signaling pathway
cellular response to epidermal growth factor stimulus
cellular response to steroid hormone stimulus
cellular response to thyroid hormone stimulus
positive regulation of receptor activity
positive regulation of hepatocyte proliferation
regulation of RNA biosynthetic process

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter binding
RNA polymerase II transcription cofactor activity
chromatin binding
transcription cofactor activity
transcription coactivator activity
receptor activity
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
thyroid hormone receptor coactivator activity
chromatin DNA binding
nuclear hormone receptor binding
mediator complex binding
vitamin D receptor binding
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
thyroid hormone receptor binding
LBD domain binding
ubiquitin protein ligase activity