115715

• Gene Symbol: SMAD2
• Gene Name: SMAD family member 2
• Gene Aliases: JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2
• Chromosome Location: Chr.18: 47833095 - 47931193 on Build GRCh38
• UniGene ID: Hs.12253
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SMAD2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001003652.3	NP_001003652.1	3	716
	NM_005901.5	NP_005892.1	3	608
	XM_005258259.3	XP_005258316.1	4	849
	XM_006722451.3	XP_006722514.1	4	861
	XM_011525984.2	XP_011524286.1	3	205
	XM_011525985.2	XP_011524287.1	5	908
	XM_017025745.1	XP_016881234.1	5	947
	XM_017025747.1	XP_016881236.1	4	834
	XM_017025748.1	XP_016881237.1	5	920
	XM_017025749.1	XP_016881238.1	3	543
	XM_017025750.1	XP_016881239.1	3	763
GenBank mRNA	AF027964.1	-	3	422
	AK312963.1	-	2	445
	BC014840.1	-	3	564	4449540
	BC025699.1	-	3	422	5221801
	BT007422.1	-	2	316
	U59911.1	-	3	415
	U65019.1	-	2	352
	U68018.1	-	2	371

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019191, NM_001277450, XM_006254946, AB010147, FQ230791, and others.
This siRNA also targets the following transcripts in Mouse: NM_001252481, NM_010754, AK007817, BC021342, AF005743, and others.

Panther Classification:

Molecular Function -

DNA-binding transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
in utero embryonic development
endoderm formation
mesoderm formation
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
SMAD protein complex assembly
zygotic specification of dorsal/ventral axis
gastrulation
negative regulation of cell proliferation
response to glucose
post-embryonic development
anterior/posterior pattern specification
positive regulation of epithelial to mesenchymal transition
regulation of transforming growth factor beta receptor signaling pathway
signal transduction involved in regulation of gene expression
insulin secretion
lung development
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
pancreas development
primary miRNA processing
activin receptor signaling pathway
somatic stem cell population maintenance
organ growth
intracellular signal transduction
nodal signaling pathway
cell fate commitment
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
paraxial mesoderm morphogenesis
embryonic foregut morphogenesis
embryonic cranial skeleton morphogenesis
regulation of binding
palate development
pericardium development
SMAD protein signal transduction
response to cholesterol
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transforming growth factor beta receptor binding
protein binding
transcription factor binding
phosphatase binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
ubiquitin protein ligase binding
activating transcription factor binding
type I transforming growth factor beta receptor binding
enhancer binding
protein homodimerization activity
SMAD binding
metal ion binding
protein heterodimerization activity
co-SMAD binding
I-SMAD binding
R-SMAD binding