116318

• Gene Symbol: RELA
• Gene Name: RELA proto-oncogene, NF-kB subunit
• Gene Aliases: NFKB3, p65
• Chromosome Location: Chr.11: 65653596 - 65662972 on Build GRCh38
• UniGene ID: Hs.502875
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RELA
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001145138.1	NP_001138610.1	8	985
	NM_001243984.1	NP_001230913.1	8	994
	NM_001243985.1	NP_001230914.1	8	994
	NM_021975.3	NP_068810.3	8	994
GenBank mRNA	AK303262.1	-	8	973
	AK308020.1	-	8	938
	AK308478.1	-	7	1040
	BC011603.1	-	7, 8	735
	BC033522.1	-	7	851	5162908
	BC110830.1	-	8	917	6019711
	L19067.1	-	7	853
	M62399.1	-	8	933

More Information

Panther Classification:

Molecular Function -

Rel homology transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
liver development
hair follicle development
stimulatory C-type lectin receptor signaling pathway
acetaldehyde metabolic process
transcription from RNA polymerase II promoter
inflammatory response
cellular defense response
aging
positive regulation of cell proliferation
organ morphogenesis
response to organic substance
response to UV-B
positive regulation of Schwann cell differentiation
cytokine-mediated signaling pathway
membrane protein intracellular domain proteolysis
positive regulation of chondrocyte differentiation
positive regulation of type I interferon production
response to muramyl dipeptide
response to progesterone
response to insulin
response to cobalamin
cellular response to hepatocyte growth factor stimulus
response to muscle stretch
Fc-epsilon receptor signaling pathway
negative regulation of protein catabolic process
response to drug
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to amino acid
response to morphine
positive regulation of interleukin-12 biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin receptor signaling pathway
regulation of inflammatory response
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
response to cAMP
defense response to virus
cellular response to hydrogen peroxide
nucleotide-binding oligomerization domain containing 2 signaling pathway
response to interleukin-1
cellular response to lipopolysaccharide
cellular response to nicotine
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to peptide hormone stimulus
negative regulation of NIK/NF-kappaB signaling
positive regulation of miRNA metabolic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
protein kinase binding
chromatin DNA binding
ubiquitin protein ligase binding
protein complex binding
activating transcription factor binding
phosphate ion binding
identical protein binding
protein homodimerization activity
actinin binding
histone deacetylase binding
transcription regulatory region DNA binding
protein heterodimerization activity
protein N-terminus binding
NF-kappaB binding
repressing transcription factor binding
ankyrin repeat binding