116560

• Gene Symbol: STAT3
• Gene Name: signal transducer and activator of transcription 3
• Gene Aliases: ADMIO, ADMIO1, APRF, HIES
• Chromosome Location: Chr.17: 42313324 - 42388505 on Build GRCh38
• UniGene ID: Hs.463059
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: STAT3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003150.3	NP_003141.2	24	3032
	NM_139276.2	NP_644805.1	24	3057
	NM_213662.1	NP_998827.1	24	2899
	XM_005257616.3	XP_005257673.2	24	3045
	XM_005257617.3	XP_005257674.2	24	3043
	XM_011525145.2	XP_011523447.1	24	3048
	XM_011525146.2	XP_011523448.1	24	2998
	XM_017024972.1	XP_016880461.1	24	2993
	XM_017024973.1	XP_016880462.1	24	2995
	XM_017024974.1	XP_016880463.1	24	2990
	XM_017024975.1	XP_016880464.1	24	3033
	XM_017024976.1	XP_016880465.1	24	2983
GenBank mRNA	AK092965.1	-	1	1612
	BC014482.1	-	24	2949	4909141

More Information

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
temperature homeostasis
eye photoreceptor cell differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein import into nucleus
movement of cell or subcellular component
acute-phase response
signal transduction
JAK-STAT cascade
nervous system development
aging
cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of hydrogen peroxide biosynthetic process
viral process
phosphorylation
cytokine-mediated signaling pathway
sexual reproduction
intracellular receptor signaling pathway
response to estradiol
cellular response to hormone stimulus
leptin-mediated signaling pathway
somatic stem cell population maintenance
miRNA mediated inhibition of translation
regulation of multicellular organism growth
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
eating behavior
negative regulation of apoptotic process
cellular response to leptin stimulus
response to leptin
response to ethanol
positive regulation of Notch signaling pathway
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of mitochondrial membrane permeability
astrocyte differentiation
regulation of cell cycle
radial glial cell differentiation
regulation of feeding behavior
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
interleukin-6-mediated signaling pathway
cellular response to organic cyclic compound
energy homeostasis
negative regulation of neuron death
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of metalloendopeptidase activity
positive regulation of gene silencing by miRNA
positive regulation of ATP biosynthetic process
negative regulation of neuron migration

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
protein phosphatase binding
chromatin DNA binding
CCR5 chemokine receptor binding
glucocorticoid receptor binding
identical protein binding
transcription regulatory region DNA binding
protein dimerization activity