118086

• Gene Symbol: PIK3R1
• Gene Name: phosphoinositide-3-kinase regulatory subunit 1
• Gene Aliases: AGM7, GRB1, IMD36, p85, p85-ALPHA
• Chromosome Location: Chr.5: 68215737 - 68301821 on Build GRCh38
• UniGene ID: Hs.132225
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PIK3R1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001242466.1	NP_001229395.1	5	657
	NM_181504.3	NP_852556.2	6	794
	NM_181523.2	NP_852664.1	12	2094
	NM_181524.1	NP_852665.1	6	926
	XM_005248542.3	XP_005248599.1	12	2117
	XM_011543493.2	XP_011541795.1	11	1747
	XM_017009585.1	XP_016865074.1	12	2886
	XM_017009586.1	XP_016865075.1	11	1707
GenBank mRNA	AF279367.1	-	6	926
	AK000121.1	-	6	840
	AK094785.1	-	5	657
	AK126345.1	-	5	2057
	AK223613.1	-	6	774
	AK294919.1	-	4	913
	AK299743.1	-	10	1123
	BC030815.1	-	6	766	4290954
	BC094795.1	-	12	2074	30528412
	JX133164.1	-	5	516
	JX133165.1	-	5	516
	M61906.1	-	11	1556

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008760659, XM_006231868, U50412, D63325.
This siRNA also targets the following transcripts in Mouse: NM_001024955, NM_001077495, U50413, AK046259, M60651, and others.

Panther Classification:

Molecular Function -

kinase modulator

Gene Ontology Categories:

Process(es)

cellular glucose homeostasis
negative regulation of cell-matrix adhesion
protein phosphorylation
phosphatidylinositol biosynthetic process
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
viral process
platelet activation
B cell differentiation
positive regulation of cell migration
T cell costimulation
positive regulation of tumor necrosis factor production
cellular response to insulin stimulus
positive regulation of RNA splicing
cellular response to UV
response to endoplasmic reticulum stress
phosphatidylinositol-3-phosphate biosynthetic process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
regulation of phosphatidylinositol 3-kinase activity
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
protein stabilization
T cell receptor signaling pathway
leukocyte migration
regulation of stress fiber assembly
NFAT protein import into nucleus
growth hormone receptor signaling pathway
positive regulation of establishment of protein localization to plasma membrane
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of glucose import in response to insulin stimulus

Function(s)

transmembrane receptor protein tyrosine kinase adaptor activity
insulin receptor binding
insulin-like growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
transcription factor binding
1-phosphatidylinositol-3-kinase activity
protein phosphatase binding
phosphatidylinositol 3-kinase regulator activity
phosphatidylinositol 3-kinase regulatory subunit binding
ErbB-3 class receptor binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity
protein heterodimerization activity