120450 Validated

• Gene Symbol: HDAC6
• Gene Name: histone deacetylase 6
• Gene Aliases: CPBHM, HD6, JM21, PPP1R90
• Chromosome Location: Chr.X: 48801377 - 48824982 on Build GRCh38
• UniGene ID: Hs.6764
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HDAC6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001321225.1	NP_001308154.1	4	338
	NM_001321226.1	NP_001308155.1	3	748
	NM_001321227.1	NP_001308156.1	3	469
	NM_001321228.1	NP_001308157.1	3	432
	NM_001321229.1	NP_001308158.1	3	286
	NM_001321230.1	NP_001308159.1	3	469
	NM_001321231.1	NP_001308160.1	3	748
	NM_006044.3	NP_006035.2	3	339
	NR_135591.1		2	212
	NR_135592.1		2	346
	NR_135593.1		2	346
	XM_017029187.1	XP_016884676.1	3	261
GenBank mRNA	AB020708.1	-	3	254
	AF132609.1	-	2	182
	AJ011972.1	-	3	275
	AK024083.1	-	3	281
	AK295884.1	-	2	199
	AK302926.1	-	3	277
	AK303012.1	-	1	180
	AL137696.1	-	3	303
	BC005872.1	-	3	708
	BC011498.1	-	3	295
	BC013737.1	-	2	164	2984860
	BC069243.1	-	3	281	6584427
	BT006649.1	-	2	182
	DA191923.1	-	2	155
	DC377684.1	-	3	339
	DC402494.1	-	4	338

More Information

Matching Taqman Gene Expression Assay:

Hs00195869_m1

Panther Classification:

Molecular Function -

chromatin/chromatin-binding, or -regulatory protein, histone modifying enzyme

Gene Ontology Categories:

Process(es)

protein polyubiquitination
transcription, DNA-templated
protein deacetylation
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
organelle organization
negative regulation of microtubule depolymerization
response to toxic substance
positive regulation of signal transduction
response to organic substance
regulation of receptor activity
regulation of autophagy
positive regulation of epithelial cell migration
negative regulation of hydrogen peroxide metabolic process
positive regulation of receptor biosynthetic process
macroautophagy
histone deacetylation
regulation of protein stability
lysosome localization
peptidyl-lysine deacetylation
cellular response to topologically incorrect protein
regulation of gene expression, epigenetic
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein complex disassembly
negative regulation of protein complex disassembly
regulation of fat cell differentiation
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
negative regulation of oxidoreductase activity
mitochondrion localization
response to misfolded protein
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
regulation of establishment of protein localization
cellular response to hydrogen peroxide
aggresome assembly
polyubiquitinated misfolded protein transport
Hsp90 deacetylation
response to growth factor
histone H3 deacetylation
cellular response to misfolded protein
positive regulation of chaperone-mediated protein complex assembly
tubulin deacetylation
mitophagy in response to mitochondrial depolarization
positive regulation of hydrogen peroxide-mediated programmed cell death
regulation of mitophagy

Function(s)

core promoter binding
actin binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
dynein complex binding