120674

• Gene Symbol: ITCH
• Gene Name: itchy E3 ubiquitin protein ligase
• Gene Aliases: ADMFD, AIF4, AIP4, NAPP1
• Chromosome Location: Chr.20: 34363235 - 34511773 on Build GRCh38
• UniGene ID: Hs.632272
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ITCH
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001257137.2	NP_001244066.1	10	1122
	NM_001257138.2	NP_001244067.1	8	857
	NM_001324197.1	NP_001311126.1	10	1143
	NM_001324198.1	NP_001311127.1	9	1020
	NM_031483.6	NP_113671.3	9	999
	XM_005260570.1	XP_005260627.1	8	915
	XM_011529079.1	XP_011527381.1	8	935
	XM_017028089.1	XP_016883578.1	9	955
	XM_017028090.1	XP_016883579.1	10	1075
	XM_017028091.1	XP_016883580.1	8	870
	XM_017028092.1	XP_016883581.1	10	1075
GenBank mRNA	AB056663.2	-	9	909
	AB209747.1	-	1	16
	AF038564.1	-	4	417
	AF095745.1	-	7	792
	AK297809.1	-	9	817
	AK304090.1	-	8	816
	AK315212.1	-	9	958
	BC011571.1	-	10	1045	4560366

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_008395, NM_001243712, AK048303, AK037940, AK220164, and others.

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

regulation of cell growth
positive regulation of T cell anergy
ubiquitin-dependent protein catabolic process
apoptotic process
inflammatory response
Notch signaling pathway
protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
protein K29-linked ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
innate immune response
positive regulation of protein catabolic process
negative regulation of JNK cascade
negative regulation of alpha-beta T cell proliferation
viral entry into host cell
negative regulation of defense response to virus
defense response to virus
nucleotide-binding oligomerization domain containing signaling pathway
protein K63-linked ubiquitination
protein K48-linked ubiquitination
regulation of protein deubiquitination

Function(s)

ubiquitin-protein transferase activity
protein binding
ligase activity
ubiquitin-like protein transferase activity
ribonucleoprotein complex binding
CXCR chemokine receptor binding
ubiquitin protein ligase activity