121031

• Gene Symbol: NLGN1
• Gene Name: neuroligin 1
• Gene Aliases: NL1
• Chromosome Location: Chr.3: 173395899 - 174291287 on Build GRCh38
• UniGene ID: Hs.478289
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NLGN1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_014932.3	NP_055747.1	7	3520
	XM_005247234.2	XP_005247291.1	6	3695
	XM_005247235.3	XP_005247292.1	6	3891
	XM_005247236.2	XP_005247293.1	6	3668
	XM_005247237.3	XP_005247294.1	5	4189
	XM_006713540.3	XP_006713603.1	7	3951
	XM_011512551.2	XP_011510853.1	8	3802
	XM_011512552.2	XP_011510854.1	7	4238
	XM_011512553.2	XP_011510855.1	4	2591
	XM_011512554.2	XP_011510856.1	4	2551
	XM_017005888.1	XP_016861377.1	7	4099
	XM_017005889.1	XP_016861378.1	7	4099
	XM_017005890.1	XP_016861379.1	7	3755
	XM_017005891.1	XP_016861380.1	7	3951
	XM_017005892.1	XP_016861381.1	7	4253
	XM_017005893.1	XP_016861382.1	8	4365
	XM_017005894.1	XP_016861383.1	7	5883
	XM_017005895.1	XP_016861384.1	7	10056
	XM_017005896.1	XP_016861385.1	7	3537
	XM_017005897.1	XP_016861386.1	7	4072
	XM_017005898.1	XP_016861387.1	6	4039
	XM_017005899.1	XP_016861388.1	6	4178
	XM_017005900.1	XP_016861389.1	7	3684
	XM_017005901.1	XP_016861390.1	6	3740
	XM_017005902.1	XP_016861391.1	7	3715
	XM_017005903.1	XP_016861392.1	6	3864
	XM_017005904.1	XP_016861393.1	6	4151
	XM_017005905.1	XP_016861394.1	4	3882
GenBank mRNA	AB028993.1	-	6	3760

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008760890, U22952.
This siRNA also targets the following transcripts in Mouse: NM_001163387, NM_138666, AK122433, AK078063, AK138209, and others.

Panther Classification:

Molecular Function -

cell adhesion molecule

Gene Ontology Categories:

Process(es)

regulation of respiratory gaseous exchange by neurological system process
protein targeting
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neuron cell-cell adhesion
nervous system development
synapse assembly
positive regulation of circadian sleep/wake cycle, wakefulness
synaptic vesicle targeting
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
neuronal signal transduction
neuron projection development
positive regulation of synaptic transmission, GABAergic
protein localization to synapse
establishment of protein localization
regulation of neuron differentiation
rhythmic process
cytoskeletal matrix organization at active zone
protein homooligomerization
protein heterotetramerization
positive regulation of filopodium assembly
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
positive regulation of dendritic spine development
negative regulation of dendritic spine morphogenesis
terminal button organization
synaptic vesicle clustering
postsynaptic membrane assembly
presynaptic membrane assembly
AMPA glutamate receptor clustering
NMDA glutamate receptor clustering
neurexin clustering involved in presynaptic membrane assembly
postsynaptic density protein 95 clustering
receptor localization to synapse
positive regulation of ruffle assembly
positive regulation of synaptic vesicle endocytosis
positive regulation of protein localization to synapse
positive regulation of intracellular signal transduction
positive regulation of synaptic vesicle exocytosis
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
positive regulation of synaptic vesicle clustering

Function(s)

receptor activity
PDZ domain binding
neurexin family protein binding
protein dimerization activity
cell adhesion molecule binding
carboxylic ester hydrolase activity
scaffold protein binding