12516

• Gene Symbol: CCL5
• Gene Name: C-C motif chemokine ligand 5
• Gene Aliases: D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
• Chromosome Location: Chr.17: 35871491 - 35880373 on Build GRCh38
• UniGene ID: Hs.514821
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CCL5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001278736.1	NP_001265665.1	4	543
	NM_002985.2	NP_002976.2	3	461
GenBank mRNA	BC008600.1	-	3	417	4185200
	CB111656.1	-	1	208
	CR980938.1	-	4	461

More Information

Panther Classification:

Molecular Function -

cytokine, intercellular signal molecule

Gene Ontology Categories:

Process(es)

MAPK cascade
dendritic cell chemotaxis
chronic inflammatory response
monocyte chemotaxis
regulation of chronic inflammatory response
calcium ion transport
cellular calcium ion homeostasis
exocytosis
chemotaxis
inflammatory response
leukocyte cell-cell adhesion
G-protein coupled receptor signaling pathway
cell-cell signaling
aging
response to virus
response to toxic substance
response to salt stress
positive regulation of activation of JAK2 kinase activity
positive regulation of macrophage chemotaxis
positive regulation of T cell chemotaxis
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
positive regulation of smooth muscle cell migration
dibenzo-p-dioxin metabolic process
positive regulation of cell migration
neutrophil chemotaxis
positive regulation of cellular biosynthetic process
activation of phospholipase D activity
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
response to insulin
positive regulation of cell-cell adhesion mediated by integrin
positive regulation of homotypic cell-cell adhesion
positive regulation of T cell proliferation
neutrophil activation
positive regulation of phosphorylation
response to drug
positive regulation of tyrosine phosphorylation of STAT protein
protein kinase B signaling
positive regulation of GTPase activity
cellular protein complex assembly
response to estrogen
negative regulation by host of viral transcription
cellular response to fibroblast growth factor stimulus
positive regulation of viral genome replication
negative regulation of viral genome replication
positive regulation of innate immune response
positive regulation of neuron differentiation
positive regulation of osteoclast differentiation
negative regulation of G-protein coupled receptor protein signaling pathway
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of translational initiation
positive regulation of JAK-STAT cascade
eosinophil chemotaxis
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of inflammatory response
regulation of insulin secretion
regulation of T cell activation
positive chemotaxis
protein tetramerization
response to glucocorticoid
positive regulation of calcium ion transport
positive regulation of mast cell chemotaxis
positive regulation of protein tyrosine kinase activity
chemokine-mediated signaling pathway
negative regulation of chemokine-mediated signaling pathway
negative regulation of T cell apoptotic process
positive regulation of T cell apoptotic process
positive regulation of ERK1 and ERK2 cascade
response to cholesterol
cellular response to amino acid stimulus
cellular response to vitamin K
cellular response to morphine
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to ethanol
cellular response to high density lipoprotein particle stimulus
cellular response to organic cyclic compound
cellular response to alkyl hydroperoxide
cellular response to transforming growth factor beta stimulus
positive regulation of monocyte chemotaxis
regulation of neuron death
negative regulation of neuron death
negative regulation of macrophage apoptotic process
positive regulation of T cell migration
positive regulation of natural killer cell chemotaxis

Function(s)

phosphatidylinositol phospholipase C activity
protein kinase activity
protein binding
chemokine activity
heparin binding
phospholipase activator activity
receptor signaling protein tyrosine kinase activator activity
CCR1 chemokine receptor binding
CCR4 chemokine receptor binding
CCR5 chemokine receptor binding
chemoattractant activity
chemokine receptor binding
protein homodimerization activity
protein self-association
chemokine receptor antagonist activity