12827

• Gene Symbol: ADAM17
• Gene Name: ADAM metallopeptidase domain 17
• Gene Aliases: ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
• Chromosome Location: Chr.2: 9488486 - 9555820 on Build GRCh38
• UniGene ID: Hs.404914
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ADAM17
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003183.5	NP_003174.3	5	815
	XM_011510375.2	XP_011508677.1	5	834
	XM_011510376.2	XP_011508678.1	5	783
	XM_017004785.1	XP_016860274.1	5	831
	XM_017004786.1	XP_016860275.1	4	503
GenBank mRNA	AK289829.1	-	5	750
	BC062687.1	-	5	769
	BC136783.1	-	5	677	9020773
	BC146658.1	-	5	787
	GQ402545.1	-	5	783
	U69611.1	-	5	714
	U69612.1	-	5	722
	U86755.1	-	5	763
	U92649.1	-	5	764

More Information

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

response to hypoxia
positive regulation of protein phosphorylation
neutrophil mediated immunity
germinal center formation
positive regulation of leukocyte chemotaxis
proteolysis
membrane protein ectodomain proteolysis
cell adhesion
epidermal growth factor receptor signaling pathway
Notch signaling pathway
Notch receptor processing
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
B cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
membrane protein intracellular domain proteolysis
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
response to lipopolysaccharide
positive regulation of chemokine production
regulation of mast cell apoptotic process
T cell differentiation in thymus
tumor necrosis factor-mediated signaling pathway
cell adhesion mediated by integrin
wound healing, spreading of epidermal cells
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
response to drug
positive regulation of epidermal growth factor-activated receptor activity
spleen development
cell motility
defense response to Gram-positive bacterium
PMA-inducible membrane protein ectodomain proteolysis
positive regulation of cellular component movement
response to high density lipoprotein particle

Function(s)

metalloendopeptidase activity
Notch binding
interleukin-6 receptor binding
integrin binding
protein binding
metallopeptidase activity
zinc ion binding
SH3 domain binding
PDZ domain binding