136456

• Gene Symbol: SIRT2
• Gene Name: sirtuin 2
• Gene Aliases: SIR2, SIR2L, SIR2L2
• Chromosome Location: Chr.19: 38878555 - 38899862 on Build GRCh38
• UniGene ID: Hs.466693
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SIRT2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001193286.1	NP_001180215.1	13	1575
	NM_012237.3	NP_036369.2	16	1735
	NM_030593.2	NP_085096.1	15	1727
	NR_034146.1		14	1658
	XM_006723111.1	XP_006723174.1	17	1683
	XM_011526654.1	XP_011524956.1	15	1620
	XM_011526655.1	XP_011524957.1	13	1435
	XM_017026500.1	XP_016881989.1	15	1659
GenBank mRNA	AB009274.1	-	15	1452
	AF083107.2	-	16	1633
	AF095714.1	-	15	1506
	AF131800.1	-	12	1230
	AF160214.1	-	15	1486
	AJ505014.1	-	13	2205
	AK025876.1	-	15	1513
	AK054642.1	-	16	1566
	AK131390.1	-	5	4400
	AK225824.1	-	15	1509
	AY030277.1	-	15	1488
	BC003012.1	-	15	1578	2820929
	BC003547.1	-	15	1578	3536728
	BF346568.1	-	1	315

More Information

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
chromatin silencing
chromatin silencing at telomere
transcription, DNA-templated
protein ADP-ribosylation
protein deacetylation
autophagy
mitotic nuclear division
regulation of exit from mitosis
negative regulation of cell proliferation
negative regulation of autophagy
negative regulation of peptidyl-threonine phosphorylation
phosphatidylinositol 3-kinase signaling
gene silencing
histone deacetylation
substantia nigra development
myelination in peripheral nervous system
regulation of myelination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to oxidative stress
peptidyl-lysine deacetylation
cellular response to hepatocyte growth factor stimulus
negative regulation of protein catabolic process
regulation of phosphorylation
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA binding
protein kinase B signaling
cellular lipid catabolic process
innate immune response
negative regulation of fat cell differentiation
positive regulation of meiotic nuclear division
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
negative regulation of oligodendrocyte differentiation
cell division
meiotic cell cycle
regulation of cell cycle
response to redox state
positive regulation of cell division
positive regulation of attachment of spindle microtubules to kinetochore
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
cellular response to caloric restriction
negative regulation of oligodendrocyte progenitor proliferation
histone H3 deacetylation
histone H4 deacetylation
cellular response to molecule of bacterial origin
cellular response to hypoxia
cellular response to epinephrine stimulus
tubulin deacetylation
positive regulation of execution phase of apoptosis
positive regulation of oocyte maturation
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of defense response to bacterium
ripoptosome assembly involved in necroptotic process
negative regulation of reactive oxygen species metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Function(s)

chromatin binding
NAD+ ADP-ribosyltransferase activity
histone deacetylase activity
protein binding
transcription factor binding
zinc ion binding
NAD-dependent histone deacetylase activity
protein deacetylase activity
NAD-dependent protein deacetylase activity
histone acetyltransferase binding
histone deacetylase binding
tubulin deacetylase activity
ubiquitin binding
NAD-dependent histone deacetylase activity (H4-K16 specific)
beta-tubulin binding
NAD+ binding