138747

• Gene Symbol: WRN
• Gene Name: Werner syndrome RecQ like helicase
• Gene Aliases: RECQ3, RECQL2, RECQL3
• Chromosome Location: Chr.8: 31033262 - 31173761 on Build GRCh38
• UniGene ID: Hs.632050
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: WRN
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000553.4	NP_000544.2	4	1116
	XM_011544639.2	XP_011542941.1	4	598
GenBank mRNA	AF091214.1	-	4	559
	AY818673.1	-	3	328
	BP279291.1	-	4	509

More Information

Panther Classification:

Molecular Function -

DNA helicase

Gene Ontology Categories:

Process(es)

telomere maintenance via recombination
telomere maintenance
DNA synthesis involved in DNA repair
strand displacement
replicative cell aging
DNA metabolic process
DNA replication
base-excision repair
double-strand break repair
cellular response to DNA damage stimulus
response to oxidative stress
brain development
aging
cell aging
cellular response to starvation
response to UV-C
multicellular organism aging
protein sumoylation
replication fork processing
nucleolus to nucleoplasm transport
DNA duplex unwinding
regulation of growth rate
regulation of apoptotic process
positive regulation of hydrolase activity
cellular response to gamma radiation
nucleic acid phosphodiester bond hydrolysis
regulation of signal transduction by p53 class mediator

Function(s)

magnesium ion binding
Y-form DNA binding
bubble DNA binding
DNA binding
DNA helicase activity
chromatin binding
ATP-dependent DNA helicase activity
helicase activity
exonuclease activity
protein binding
ATP binding
3'-5' exonuclease activity
four-way junction helicase activity
ATPase activity
manganese ion binding
protein complex binding
protein homodimerization activity
3'-5' DNA helicase activity
ATP-dependent 3'-5' DNA helicase activity
G-quadruplex DNA binding