138752

• Gene Symbol: TNF
• Gene Name: tumor necrosis factor
• Gene Aliases: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F
• Chromosome Location: Chr.6: 31575567 - 31578336 on Build GRCh38
• UniGene ID: Hs.241570
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TNF
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000594.3	NP_000585.2	4	889
GenBank mRNA	BC028148.1	-	4	871	5217636
	M10988.1	-	4	799
	X01394.1	-	4	866

More Information

Gene Ontology Categories:

Process(es)

protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPKKK activity
activation of MAPK activity
positive regulation of cytokine production
positive regulation of protein phosphorylation
chronic inflammatory response to antigenic stimulus
negative regulation of cytokine secretion involved in immune response
positive regulation of chronic inflammatory response to antigenic stimulus
positive regulation of humoral immune response mediated by circulating immunoglobulin
glucose metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
humoral immune response
I-kappaB kinase/NF-kappaB signaling
JNK cascade
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
response to virus
response to salt stress
positive regulation of gene expression
negative regulation of gene expression
negative regulation of alkaline phosphatase activity
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipid storage
extracellular matrix organization
osteoclast differentiation
sequestering of triglyceride
cortical actin cytoskeleton organization
positive regulation of protein complex assembly
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
negative regulation of interleukin-6 production
positive regulation of chemokine production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
receptor biosynthetic process
positive regulation of peptidyl-serine phosphorylation
tumor necrosis factor-mediated signaling pathway
positive regulation of heterotypic cell-cell adhesion
negative regulation of myosin-light-chain-phosphatase activity
positive regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of protein complex disassembly
positive regulation of protein complex disassembly
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAP kinase activity
protein kinase B signaling
positive regulation of JUN kinase activity
negative regulation of growth of symbiont in host
negative regulation of viral genome replication
positive regulation of chemokine biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of nitric oxide biosynthetic process
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
positive regulation of cell adhesion
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of translational initiation by iron
negative regulation of glucose import
embryonic digestive tract development
positive regulation of smooth muscle cell proliferation
positive regulation of cytokine secretion
positive regulation of phagocytosis
regulation of insulin secretion
defense response to Gram-positive bacterium
leukocyte tethering or rolling
negative regulation of lipid catabolic process
regulation of immunoglobulin secretion
positive regulation of membrane protein ectodomain proteolysis
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein transport
response to glucocorticoid
positive regulation of NFAT protein import into nucleus
positive regulation of hair follicle development
positive regulation of protein kinase B signaling
positive regulation of vitamin D biosynthetic process
positive regulation of calcidiol 1-monooxygenase activity
epithelial cell proliferation involved in salivary gland morphogenesis
regulation of branching involved in salivary gland morphogenesis
negative regulation of branching involved in lung morphogenesis
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to nicotine
cellular response to organic cyclic compound
death-inducing signaling complex assembly
positive regulation of mononuclear cell migration
positive regulation of podosome assembly
establishment of protein localization to plasma membrane
extrinsic apoptotic signaling pathway
necroptotic signaling pathway
positive regulation of NIK/NF-kappaB signaling
positive regulation of superoxide dismutase activity
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
positive regulation of leukocyte adhesion to vascular endothelial cell
positive regulation of leukocyte adhesion to arterial endothelial cell
positive regulation of protein localization to cell surface
positive regulation of ceramide biosynthetic process
positive regulation of blood microparticle formation
positive regulation of chemokine (C-X-C motif) ligand 2 production
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

protease binding
cytokine activity
tumor necrosis factor receptor binding
protein binding
identical protein binding
transcription regulatory region DNA binding