139328

• Gene Symbol: TNFSF11
• Gene Name: tumor necrosis factor superfamily member 11
• Gene Aliases: CD254, ODF, OPGL, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2, sOdf
• Chromosome Location: Chr.13: 42562736 - 42608013 on Build GRCh38
• UniGene ID: Hs.333791
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TNFSF11
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_003701.3	NP_003692.1	5	1230
	NM_033012.3	NP_143026.1	7	1391
	XM_011535280.2	XP_011533582.1	5	935
	XM_017020802.1	XP_016876291.1	5	1037
	XM_017020803.1	XP_016876292.1	5	884
GenBank mRNA	AF013171.1	-	4	864
	AF019047.1	-	5	1209
	AF053712.1	-	5	1265
	BC040889.1	-	7	1391

More Information

Gene Ontology Categories:

Process(es)

ossification
osteoclast proliferation
monocyte chemotaxis
immune response
activation of JUN kinase activity
organ morphogenesis
cytokine-mediated signaling pathway
osteoclast differentiation
tumor necrosis factor-mediated signaling pathway
mammary gland epithelial cell proliferation
positive regulation of homotypic cell-cell adhesion
paracrine signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
bone resorption
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of transcription from RNA polymerase II promoter
positive regulation of T cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
positive regulation of corticotropin-releasing hormone secretion
positive regulation of protein kinase B signaling
calcium ion homeostasis
mammary gland alveolus development
ERK1 and ERK2 cascade
positive regulation of fever generation by positive regulation of prostaglandin secretion
TNFSF11-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
positive regulation of intracellular signal transduction
positive regulation of osteoclast development

Function(s)

cytokine activity
tumor necrosis factor receptor binding
tumor necrosis factor receptor superfamily binding