141229

• Gene Symbol: RFFL
• Gene Name: ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
• Gene Aliases: CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L
• Chromosome Location: Chr.17: 35009112 - 35089329 on Build GRCh38
• UniGene ID: Hs.13680
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RFFL
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001017368.1	NP_001017368.1	2, 3	361
	NR_037713.1		2, 3	421
GenBank mRNA	AF434816.1	-	1, 2	188
	AK093112.1	-	2, 3	367
	AK308689.1	-	2, 3	430
	AY098935.1	-	1, 2	188
	BC015681.2	-	1, 2	30
	BC028424.1	-	2, 3	391	4826613
	CR933651.1	-	2, 3	361
	DB459719.1	-	2, 3	416

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001004068, XM_006246970, XM_006246979, XM_008767954, XM_006246978, and others.
This siRNA also targets the following transcripts in Mouse: NM_001164569, NM_001007465, NM_001164570, NM_026097, AF434814, and others.

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

ubiquitin-dependent protein catabolic process
apoptotic process
regulation of fibroblast migration
negative regulation of tumor necrosis factor-mediated signaling pathway
regulation of TOR signaling
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K48-linked ubiquitination
negative regulation of signal transduction by p53 class mediator
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Function(s)

protease binding
p53 binding
protein binding
zinc ion binding
ligase activity
protein kinase binding
ubiquitin protein ligase binding
ubiquitin protein ligase activity