142435

Gene Symbol:

RAF1 RAP1A

Gene Name:

Raf-1 proto-oncogene, serine/threonine kinase

RAP1A, member of RAS oncogene family

Gene Aliases:

CMD1NN, CRAF, NS5, Raf-1, c-Raf

C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21

Chromosome Location:

Chr.3: 12583601 - 12664201 on Build GRCh38

Chromosome Location:

Chr.1: 111542223 - 111716695 on Build GRCh38

UniGene ID:

Hs.159130

Hs.190334

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: RAF1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002880.3	NP_002871.1	3	653
	XM_005265355.2	XP_005265412.1	3	381
	XM_005265357.2	XP_005265414.1	3	569
	XM_011533974.2	XP_011532276.1	4	696
	XM_017006966.1	XP_016862455.1	3	357
GenBank mRNA	AK226028.1	-	3	569
	AK312248.1	-	3	547
	BC018119.2	-	3	567	3904404
	KU178297.1	-	2	238
	KU178298.1	-	2	238
	KU178299.1	-	2	238
	X03484.1	-	3	367

Gene Symbol: RAP1A
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AB051846.1	-		1327

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, small GTPase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
response to hypoxia
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
apoptotic process
signal transduction
activation of adenylate cyclase activity
heart development
cell proliferation
negative regulation of cell proliferation
cell differentiation
platelet activation
thyroid gland development
negative regulation of protein complex assembly
positive regulation of peptidyl-serine phosphorylation
ion transmembrane transport
somatic stem cell population maintenance
regulation of Rho protein signal transduction
insulin secretion involved in cellular response to glucose stimulus
response to muscle stretch
wound healing
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
intermediate filament cytoskeleton organization
regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
neurotrophin TRK receptor signaling pathway
thymus development
face development
death-inducing signaling complex assembly
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of cell motility

Function(s)

protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
small GTPase binding
mitogen-activated protein kinase kinase binding
identical protein binding
metal ion binding
protein heterodimerization activity