143204

• Gene Symbol: LEP
• Gene Name: leptin
• Gene Aliases: LEPD, OB, OBS
• Chromosome Location: Chr.7: 128241201 - 128257629 on Build GRCh38
• UniGene ID: Hs.194236
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: LEP
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000230.2	NP_000221.1	3	238
	XM_005250340.4	XP_005250397.1	3	312
GenBank mRNA	AF008123.1	-	2	198
	AK313553.1	-	3	236
	BC060830.1	-	3	236	30333193
	BC069323.1	-	2	232	7262097
	BC069452.1	-	2	232	7262109
	BC069527.1	-	2	232	7262121
	D49487.1	-	2	195
	DA762132.1	-	3	238
	U18915.1	-	2	181
	U43653.1	-	2	237

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_013076, XM_008762762, D49653, D45862, U48849, and others.

Panther Classification:

Molecular Function -

peptide hormone

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
angiogenesis
ovulation from ovarian follicle
response to hypoxia
positive regulation of cytokine production
placenta development
regulation of endothelial cell proliferation
response to dietary excess
cardiac muscle hypertrophy
glucose metabolic process
regulation of gluconeogenesis
energy reserve metabolic process
glycerol biosynthetic process
lipid metabolic process
fatty acid beta-oxidation
tyrosine phosphorylation of STAT protein
female pregnancy
circadian rhythm
cholesterol metabolic process
bile acid metabolic process
regulation of blood pressure
adult feeding behavior
negative regulation of autophagy
negative regulation of lipid storage
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
sexual reproduction
central nervous system neuron development
insulin secretion
T cell differentiation
regulation of intestinal cholesterol absorption
positive regulation of TOR signaling
negative regulation of appetite
prostaglandin secretion
response to estradiol
regulation of natural killer cell activation
regulation of natural killer cell proliferation
response to insulin
response to vitamin E
leptin-mediated signaling pathway
positive regulation of luteinizing hormone secretion
positive regulation of peroxisome proliferator activated receptor signaling pathway
bone mineralization involved in bone maturation
negative regulation of appetite by leptin-mediated signaling pathway
positive regulation of T cell proliferation
regulation of natural killer cell mediated cytotoxicity
hormone metabolic process
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
eating behavior
negative regulation of apoptotic process
positive regulation of ion transport
positive regulation of MAPK cascade
cellular response to leptin stimulus
response to ethanol
positive regulation of myeloid cell differentiation
regulation of angiogenesis
negative regulation of vasoconstriction
negative regulation of glucose import
positive regulation of JAK-STAT cascade
positive regulation of insulin receptor signaling pathway
regulation of bone remodeling
positive regulation of follicle-stimulating hormone secretion
positive regulation of developmental growth
regulation of insulin secretion
regulation of steroid biosynthetic process
intestinal absorption
leukocyte tethering or rolling
regulation of nitric-oxide synthase activity
regulation of cell cycle
positive regulation of protein kinase B signaling
regulation of lipoprotein lipid oxidation
adipose tissue development
negative regulation of cartilage development
negative regulation of glucagon secretion
cellular response to L-ascorbic acid
cellular response to retinoic acid
interleukin-6 secretion
interleukin-8 secretion
regulation of brown fat cell differentiation
bone growth
regulation of cytokine production involved in inflammatory response
positive regulation of p38MAPK cascade
positive regulation of fat cell apoptotic process
activation of protein kinase C activity
positive regulation of STAT protein import into nucleus
positive regulation of reactive oxygen species metabolic process
negative regulation of glutamine transport
positive regulation of hepatic stellate cell activation

Function(s)

hormone activity
growth factor activity
peptide hormone receptor binding