143856

• Gene Symbol: NFKB1
• Gene Name: nuclear factor kappa B subunit 1
• Gene Aliases: CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
• Chromosome Location: Chr.4: 102501329 - 102617302 on Build GRCh38
• UniGene ID: Hs.618430
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NFKB1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001165412.1	NP_001158884.1	24	3371
	NM_001319226.1	NP_001306155.1	24	3181
	NM_003998.3	NP_003989.2	24	3374
	XM_011532006.2	XP_011530308.1	25	3141
	XM_011532008.2	XP_011530310.1	22	2755
GenBank mRNA	AK122850.1	-	17	3503
	AK291450.1	-	24	3035
	BC033210.1	-	12	1652
	BC051765.1	-	24	3374	6500087
	CR749522.1	-	24	3131
	M55643.1	-	24	3088
	M58603.1	-	24	3301

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001276711, XM_006233358, XM_006233360, FQ232433, L26267.
This siRNA also targets the following transcripts in Mouse: NM_008689, AY521463, AK157915, L28117, AK159423, and others.

Panther Classification:

Molecular Function -

Rel homology transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
stimulatory C-type lectin receptor signaling pathway
transcription from RNA polymerase II promoter
apoptotic process
inflammatory response
response to oxidative stress
I-kappaB kinase/NF-kappaB signaling
positive regulation of macrophage derived foam cell differentiation
positive regulation of lipid storage
negative regulation of calcidiol 1-monooxygenase activity
negative regulation of vitamin D biosynthetic process
membrane protein intracellular domain proteolysis
negative regulation of cellular protein metabolic process
negative regulation of cholesterol transport
positive regulation of type I interferon production
response to muscle stretch
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
negative regulation of apoptotic process
negative regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to copper ion
negative regulation of inflammatory response
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to nicotine
cellular response to carbohydrate stimulus
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to dsRNA
cellular response to peptide hormone stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of hyaluronan biosynthetic process
cellular response to diterpene
cellular response to glucoside
cellular response to brain-derived neurotrophic factor stimulus
positive regulation of miRNA metabolic process

Function(s)

regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
heat shock protein binding
identical protein binding
protein homodimerization activity
actinin binding
transcription regulatory region DNA binding
protein heterodimerization activity