144071

• Gene Symbol: MRE11A
• Gene Name: MRE11 homolog A, double strand break repair nuclease
• Gene Aliases: ATLD, HNGS1, MRE11, MRE11B
• Chromosome Location: Chr.11: 94415570 - 94512701 on Build GRCh38
• UniGene ID: Hs.192649
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MRE11A
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_005590.3	NP_005581.2	9	1234
	NM_005591.3	NP_005582.1	9	1127
	XM_005274008.3	XP_005274065.1	7	842
	XM_006718842.3	XP_006718905.1	9	1234
	XM_011542837.2	XP_011541139.1	9	1656
	XM_017017772.1	XP_016873261.1	9	1234
	XM_017017773.1	XP_016873262.1	9	1127
GenBank mRNA	AF022778.1	-	9	1108
	AF073362.1	-	8	938
	AK095388.1	-	9	1236
	AK308318.1	-	9	1125
	BC017823.1	-	9	1170
	BC063458.1	-	8	1035	5181691
	U37359.1	-	9	1109

More Information

Gene Ontology Categories:

Process(es)

regulation of mitotic recombination
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
sister chromatid cohesion
mitotic G2 DNA damage checkpoint
synapsis
reciprocal meiotic recombination
heart development
cell proliferation
viral process
intra-S DNA damage checkpoint
telomeric 3' overhang formation
positive regulation of protein autophosphorylation
positive regulation of telomere maintenance
positive regulation of type I interferon production
DNA duplex unwinding
negative regulation of DNA endoreduplication
positive regulation of kinase activity
negative regulation of apoptotic process
negative regulation of viral entry into host cell
nucleic acid phosphodiester bond hydrolysis
cell-cell adhesion
regulation of signal transduction by p53 class mediator

Function(s)

single-stranded DNA endodeoxyribonuclease activity
DNA binding
double-stranded DNA binding
ATP-dependent DNA helicase activity
nuclease activity
endodeoxyribonuclease activity
protein binding
protein C-terminus binding
3'-5' exonuclease activity
manganese ion binding
cadherin binding involved in cell-cell adhesion