144712

• Gene Symbol: GCLC
• Gene Name: glutamate-cysteine ligase catalytic subunit
• Gene Aliases: GCL, GCS, GLCL, GLCLC
• Chromosome Location: Chr.6: 53497341 - 53545129 on Build GRCh38
• UniGene ID: Hs.654465
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: GCLC
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001197115.1	NP_001184044.1	3	775
	NM_001498.3	NP_001489.1	3	775
	XM_017010749.1	XP_016866238.1	3	365
GenBank mRNA	AB262176.1	-	3	678
	AB516284.1	-	3	291
	AK304288.1	-	3	303
	AK313480.1	-	3	685
	BC022487.1	-	3	682
	BC039894.1	-	3	373	6052162
	M90656.1	-	3	383

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012815, BC081702, J05181.
This siRNA also targets the following transcripts in Mouse: NM_010295, AK144339, U85414, AK169676, U85498, and others.

Panther Classification:

Molecular Function -

ligase

Gene Ontology Categories:

Process(es)

sulfur amino acid metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
response to oxidative stress
apoptotic mitochondrial changes
response to heat
response to xenobiotic stimulus
response to hormone
L-ascorbic acid metabolic process
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
negative regulation of transcription, DNA-templated
response to arsenic-containing substance
regulation of blood vessel size
response to nitrosative stress
regulation of mitochondrial depolarization
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

magnesium ion binding
glutamate-cysteine ligase activity
ATP binding
glutamate binding
ADP binding
protein heterodimerization activity
coenzyme binding