146377

• Gene Symbol: CD74
• Gene Name: CD74 molecule
• Gene Aliases: DHLAG, HLADG, II, Ia-GAMMA
• Chromosome Location: Chr.5: 150401637 - 150412936 on Build GRCh38
• UniGene ID: Hs.436568
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CD74
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001025158.2	NP_001020329.1	6	1046
	NM_001025159.2	NP_001020330.1	9	1422
	NM_004355.3	NP_004346.1	8	1230
	XM_017010089.1	XP_016865578.1	8	1710
	XM_017010090.1	XP_016865579.1	7	1518
GenBank mRNA	AK292076.1	-	8	1045
	AK300669.1	-	7	781
	BC018726.1	-	8	1054	4853578
	BC024272.1	-	6	879	4763768
	K01144.1	-	8	1094
	X00497.1	-	8	1049

More Information

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPK activity
prostaglandin biosynthetic process
positive regulation of cytokine-mediated signaling pathway
positive regulation of dendritic cell antigen processing and presentation
negative regulation of peptide secretion
positive regulation of type 2 immune response
negative regulation of mature B cell apoptotic process
protein complex assembly
intracellular protein transport
defense response
signal transduction
cell proliferation
immunoglobulin mediated immune response
antigen processing and presentation of endogenous antigen
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of B cell proliferation
macrophage migration inhibitory factor signaling pathway
regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
T cell selection
positive thymic T cell selection
negative thymic T cell selection
negative regulation of T cell differentiation
positive regulation of T cell differentiation
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
chaperone mediated protein folding requiring cofactor
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of chemokine (C-X-C motif) ligand 2 production

Function(s)

beta-amyloid binding
cytokine receptor activity
protein binding
cytokine binding
MHC class II protein complex binding
macrophage migration inhibitory factor binding
MHC class II protein binding
MHC class II protein binding, via antigen binding groove
identical protein binding
protein binding involved in protein folding
nitric-oxide synthase binding