146902

• Gene Symbol: BTK
• Gene Name: Bruton tyrosine kinase
• Gene Aliases: AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
• Chromosome Location: Chr.X: 101349447 - 101390796 on Build GRCh38
• UniGene ID: Hs.159494
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: BTK
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000061.2	NP_000052.1	11	1108
	NM_001287344.1	NP_001274273.1	11	1264
	NM_001287345.1	NP_001274274.1	12	1273
GenBank mRNA	AK057105.1	-	12	1227
	AK225577.1	-	11	1070
	AK309851.1	-	11	1250
	AK314382.1	-	11	1075
	BC109079.1	-	11	1040	40034287
	BC109080.1	-	11	1040	40034289
	KF241986.1	-	10	915
	X58957.1	-	11	1047

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001007798, FQ215667, AY787790.
This siRNA also targets the following transcripts in Mouse: NM_013482, L08967, L10627, L29788.

Gene Ontology Categories:

Process(es)

negative regulation of cytokine production
adaptive immune response
regulation of B cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
regulation of B cell apoptotic process
transcription, DNA-templated
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
I-kappaB kinase/NF-kappaB signaling
mesoderm development
peptidyl-tyrosine phosphorylation
calcium-mediated signaling
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
B cell activation
regulation of cell proliferation
innate immune response
positive regulation of B cell differentiation
cell maturation
B cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
apoptotic signaling pathway

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
phosphatidylinositol-3,4,5-trisphosphate binding
identical protein binding
metal ion binding