150309

• Gene Symbol: Psen1
• Gene Name: presenilin 1
• Gene Aliases: Ad3h, PS-1, PS1, S182
• Chromosome Location: Chr.12: 83688146 - 83738446 on Build GRCm38
• UniGene ID: Mm.998
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Psen1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_008943.2	NP_032969.1	4	715
GenBank mRNA	AF149111.1	-	2	227
	AK134232.1	-	4	398
	AK134615.1	-	4	437
	AK148101.1	-	4	436
	AK165984.1	-	4	436
	BC014744.1	-	4	466	4511140
	BC030409.1	-	4	390	5133302
	BC071233.1	-	4	454	3673609
	L42177.1	-	4	411

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019163, XM_006240321, XM_006240322, D82363, BC070887, and others.

Panther Classification:

Molecular Function -

aspartic protease

Gene Ontology Categories:

Process(es)

autophagosome assembly
negative regulation of transcription from RNA polymerase II promoter
activation of MAPKK activity
blood vessel development
cell fate specification
somitogenesis
neuron migration
positive regulation of receptor recycling
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart looping
hematopoietic progenitor cell differentiation
T cell activation involved in immune response
myeloid leukocyte differentiation
negative regulation of protein kinase activity
protein glycosylation
proteolysis
membrane protein ectodomain proteolysis
calcium ion transport
mitochondrial transport
cellular calcium ion homeostasis
autophagy
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
cell adhesion
negative regulation of epidermal growth factor-activated receptor activity
regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
Notch receptor processing
brain development
heart development
learning or memory
memory
embryo development
post-embryonic development
protein transport
L-glutamate transport
choline transport
synaptic vesicle targeting
single organismal cell-cell adhesion
protein processing
cerebral cortex cell migration
Cajal-Retzius cell differentiation
dorsal/ventral neural tube patterning
cerebral cortex development
neurogenesis
neuron differentiation
embryonic limb morphogenesis
forebrain development
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
endoplasmic reticulum calcium ion homeostasis
beta-amyloid formation
segmentation
intracellular signal transduction
locomotion
regulation of phosphorylation
anagen
amyloid precursor protein catabolic process
myeloid dendritic cell differentiation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of catalytic activity
regulation of protein binding
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
skin morphogenesis
cellular protein metabolic process
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
regulation of synaptic plasticity
thymus development
neuron development
skeletal system morphogenesis
brain morphogenesis
beta-amyloid metabolic process
epithelial cell proliferation
negative regulation of axonogenesis
positive regulation of coagulation
T cell receptor signaling pathway
neuron apoptotic process
negative regulation of ubiquitin-protein transferase activity
smooth endoplasmic reticulum calcium ion homeostasis
protein maturation
regulation of synaptic transmission, glutamatergic
canonical Wnt signaling pathway
regulation of resting membrane potential
positive regulation of dendritic spine development
calcium ion transmembrane transport
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic signaling pathway

Function(s)

endopeptidase activity
aspartic-type endopeptidase activity
calcium channel activity
protein binding
beta-catenin binding
peptidase activity
hydrolase activity
PDZ domain binding
aspartic endopeptidase activity, intramembrane cleaving
cadherin binding