150390

• Gene Symbol: Ptpn2
• Gene Name: protein tyrosine phosphatase, non-receptor type 2
• Gene Aliases: AI325124, Ptpt, TC-PTP
• Chromosome Location: Chr.18: 67665501 - 67724748 on Build GRCm38
• UniGene ID: Mm.260433
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ptpn2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001127177.1	NP_001120649.1	2, 3	274
	NM_008977.3	NP_033003.1	2, 3	274
GenBank mRNA	AK014528.1	-	2, 3	242
	AK076072.1	-	2, 3	227
	AK132013.1	-	2, 3	237
	BC008269.1	-	2, 3	248	3602983
	CA560046.1	-	2, 3	274
	M80739.1	-	2, 3	229
	M81477.1	-	2, 3	229
	S52655.1	-	2, 3	224

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_002828, NM_080422, NM_001207013, NM_080423, BG699440, and others.
This siRNA also targets the following transcripts in Rat: NM_053990, XM_008772080, XM_006254854, XM_006254855, XM_008772081, and others.

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

protein dephosphorylation
negative regulation of cell proliferation
insulin receptor signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipid storage
dephosphorylation
B cell differentiation
T cell differentiation
erythrocyte differentiation
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of tyrosine phosphorylation of Stat6 protein
glucose homeostasis
negative regulation of macrophage differentiation
positive regulation of gluconeogenesis
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of T cell receptor signaling pathway
negative regulation of chemotaxis
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
negative regulation of protein tyrosine kinase activity
negative regulation of interleukin-6-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of interleukin-2-mediated signaling pathway
negative regulation of prolactin signaling pathway
negative regulation of interleukin-4-mediated signaling pathway
negative regulation of macrophage colony-stimulating factor signaling pathway
negative regulation of positive thymic T cell selection
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of PERK-mediated unfolded protein response
negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Function(s)

phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
integrin binding
protein binding
hydrolase activity
phosphatase activity
protein kinase binding
syntaxin binding
receptor tyrosine kinase binding