150910

• Gene Symbol: Snca
• Gene Name: synuclein, alpha
• Gene Aliases: NACP, alphaSYN
• Chromosome Location: Chr.6: 60731573 - 60829855 on Build GRCm38
• UniGene ID: Mm.17484
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Snca
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001042451.2	NP_001035916.1	6	1172
	NM_009221.2	NP_033247.1	6	1076
GenBank mRNA	AF033261.1	-	6	999
	AF179273.1	-	6	1080
	AK156316.1	-	6	1008
	BC046764.1	-	6	915	5693785

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019169, AY550006, AY550005, BC087682.

Panther Classification:

Molecular Function -

membrane trafficking regulatory protein

Gene Ontology Categories:

Process(es)

microglial cell activation
positive regulation of receptor recycling
negative regulation of protein phosphorylation
positive regulation of neurotransmitter secretion
synaptic transmission, dopaminergic
fatty acid metabolic process
neutral lipid metabolic process
phospholipid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial membrane organization
chemical synaptic transmission
adult locomotory behavior
response to iron(II) ion
regulation of phospholipase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of glutamate secretion
regulation of dopamine secretion
negative regulation of microtubule polymerization
receptor internalization
protein destabilization
response to magnesium ion
negative regulation of transporter activity
response to lipopolysaccharide
negative regulation of monooxygenase activity
positive regulation of peptidyl-serine phosphorylation
response to interferon-gamma
cellular response to oxidative stress
negative regulation of histone acetylation
regulation of locomotion
dopamine biosynthetic process
dopamine metabolic process
response to drug
mitochondrial ATP synthesis coupled electron transport
regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
positive regulation of endocytosis
negative regulation of exocytosis
negative regulation of dopamine metabolic process
regulation of neurotransmitter secretion
behavioral response to cocaine
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
synaptic vesicle endocytosis
synaptic vesicle transport
positive regulation of synaptic transmission
synapse organization
regulation of acyl-CoA biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
negative regulation of dopamine uptake involved in synaptic transmission
negative regulation of serotonin uptake
negative regulation of norepinephrine uptake
oxidation-reduction process
excitatory postsynaptic potential
long-term synaptic potentiation
positive regulation of inositol phosphate biosynthetic process
membrane organization
negative regulation of thrombin receptor signaling pathway
response to interleukin-1
cellular response to copper ion
positive regulation of protein serine/threonine kinase activity
regulation of neuron death
positive regulation of glutathione peroxidase activity
positive regulation of hydrogen peroxide catabolic process
regulation of reactive oxygen species metabolic process

Function(s)

magnesium ion binding
copper ion binding
calcium ion binding
protein binding
phospholipid binding
microtubule binding
ferrous iron binding
zinc ion binding
oxidoreductase activity
kinesin binding
enzyme binding
protein domain specific binding
Hsp70 protein binding
histone binding
identical protein binding
alpha-tubulin binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
phospholipase binding
dynein binding
metal ion binding
protein N-terminus binding
tau protein binding
beta-tubulin binding
arachidonic acid binding
phosphoprotein binding